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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
24
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pubmed:dateCreated |
2007-10-22
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|
pubmed:abstractText |
5-Arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones (7,8) were synthesized and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1beta. This in vitro model has proven to be a useful experimental model to reproduce the mechanisms involved in arthritic diseases. The cell viability, the amount of GAGs, the production of NO and PGE(2) and the inhibition of MMP-3 were measured. Several thiazolidinones 7 and 8 exhibited the ability to block the production or action of the degenerative factors induced by IL-1beta.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Dec
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pubmed:issn |
1464-3391
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pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:day |
15
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|
pubmed:volume |
15
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
7618-25
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|
pubmed:meshHeading |
pubmed-meshheading:17889545-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:17889545-Arthritis,
pubmed-meshheading:17889545-Cell Survival,
pubmed-meshheading:17889545-Cells, Cultured,
pubmed-meshheading:17889545-Chondrocytes,
pubmed-meshheading:17889545-Drug Evaluation, Preclinical,
pubmed-meshheading:17889545-Humans,
pubmed-meshheading:17889545-Imines,
pubmed-meshheading:17889545-Indomethacin,
pubmed-meshheading:17889545-Interleukin-1beta,
pubmed-meshheading:17889545-Models, Biological,
pubmed-meshheading:17889545-Reference Standards,
pubmed-meshheading:17889545-Thiazolidines
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pubmed:year |
2007
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|
pubmed:articleTitle |
Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures.
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|
pubmed:affiliation |
Dipartimento Farmaco-chimico, Università di Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
