Source:http://linkedlifedata.com/resource/pubmed/id/17889544
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2007-10-15
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| pubmed:abstractText |
The cytotoxicity of four triterpenoids, euscaphic acid (1), tormentic acid (2), 2alpha-acetyl tormentic acid (3), and 3beta-acetyl tormentic acid (4), isolated from the roots of Cecropia lyratiloba (Moraceae) by countercurrent chromatography, was evaluated in vitro in sensitive and multidrug resistant leukemia cell lines. A structure/activity relationship analysis of the compounds was performed. Acetylation of compound 2 at C2 increased its activity by a factor of 2 while acetylation at C3 had a smaller effect. Compound 1 induces death by activation of caspase-3, dependent apoptotic pathway. Furthermore, the four triterpenoids were also active toward a multidrug resistant (MDR) leukemia cell line, overexpressing glycoprotein-P (P-gp). These results reveal the potential of the terpenoids as source for the development of new anti-neoplastic and anti-MDR drugs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0968-0896
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
7355-60
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| pubmed:meshHeading |
pubmed-meshheading:17889544-Antineoplastic Agents,
pubmed-meshheading:17889544-Apoptosis,
pubmed-meshheading:17889544-Cecropia Plant,
pubmed-meshheading:17889544-Cell Line, Tumor,
pubmed-meshheading:17889544-Cell Survival,
pubmed-meshheading:17889544-Dose-Response Relationship, Drug,
pubmed-meshheading:17889544-Drug Resistance, Multiple,
pubmed-meshheading:17889544-Drug Resistance, Neoplasm,
pubmed-meshheading:17889544-Drug Screening Assays, Antitumor,
pubmed-meshheading:17889544-Humans,
pubmed-meshheading:17889544-K562 Cells,
pubmed-meshheading:17889544-Leukemia,
pubmed-meshheading:17889544-Molecular Conformation,
pubmed-meshheading:17889544-Plant Roots,
pubmed-meshheading:17889544-Sensitivity and Specificity,
pubmed-meshheading:17889544-Stereoisomerism,
pubmed-meshheading:17889544-Structure-Activity Relationship,
pubmed-meshheading:17889544-Triterpenes
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines.
|
| pubmed:affiliation |
Lab. de Imunologia Celular, Instituto de Biofísica Carlos Chagas Filho, CCS B1 G, Universidade Federal do Rio de Janeiro, 21949-900 Rio de Janeiro, RJ, Brazil.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|