Source:http://linkedlifedata.com/resource/pubmed/id/17888546
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-3-16
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| pubmed:abstractText |
In this prospective study we examined whether total cholesterol and the oxysterols 24S- and 27-hydroxycholesterol were related to cognitive performance and rate of cognitive decline in elderly, and whether these associations were modified by ApoE epsilon 4. Data were collected during 6 years of follow-up as part of the Longitudinal Aging Study Amsterdam (N=1181, age >or=65 years), and analyzed using generalized estimating equations. Cognitive performance was measured with the mini-mental state examination (general cognition), the auditory verbal learning test (memory) and the coding task (information processing speed). Lower cholesterol at baseline was negatively associated with both general cognition (p=.012) and information processing speed (p=.045). ApoE modified the association between cholesterol and cognitive decline, and the association between the ratio of 27-hydroxycholesterol to cholesterol and cognitive functioning. In ApoE epsilon 4 carriers, lower cholesterol was related to a higher rate of decline on information processing speed (p=.006), and a higher ratio of 27-hydroxycholesterol to cholesterol was related to a lower level of general performance (p=.002) and memory functioning (p=.045). The results implicate that lower total cholesterol may be considered as a frailty marker, predictive of lower cognitive functioning in elderly.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/27-hydroxycholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein E4,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxycholesterols
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1558-1497
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
534-45
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| pubmed:dateRevised |
2011-8-29
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| pubmed:meshHeading |
pubmed-meshheading:17888546-Age of Onset,
pubmed-meshheading:17888546-Aged,
pubmed-meshheading:17888546-Aged, 80 and over,
pubmed-meshheading:17888546-Aging,
pubmed-meshheading:17888546-Apolipoprotein E4,
pubmed-meshheading:17888546-Biological Markers,
pubmed-meshheading:17888546-Causality,
pubmed-meshheading:17888546-Cholesterol,
pubmed-meshheading:17888546-Cognition,
pubmed-meshheading:17888546-Cognition Disorders,
pubmed-meshheading:17888546-Female,
pubmed-meshheading:17888546-Genotype,
pubmed-meshheading:17888546-Humans,
pubmed-meshheading:17888546-Hydroxycholesterols,
pubmed-meshheading:17888546-Hypercholesterolemia,
pubmed-meshheading:17888546-Longitudinal Studies,
pubmed-meshheading:17888546-Male,
pubmed-meshheading:17888546-Memory,
pubmed-meshheading:17888546-Memory Disorders,
pubmed-meshheading:17888546-Middle Aged,
pubmed-meshheading:17888546-Neuropsychological Tests,
pubmed-meshheading:17888546-Predictive Value of Tests,
pubmed-meshheading:17888546-Severity of Illness Index
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| pubmed:year |
2009
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| pubmed:articleTitle |
Total cholesterol and oxysterols: early markers for cognitive decline in elderly?
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| pubmed:affiliation |
Longitudinal Aging Study Amsterdam, EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. tn.vandenkommer@vumc.nl
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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