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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-21
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pubmed:abstractText |
Clozapine is a unique atypical antipsychotic with superior efficacy in treatment-resistant schizophrenia. Plasma concentration of clozapine and its major metabolite N-desmethylclozapine (NDMC) as well as the ratio of NDMC to clozapine have been reported to be predictors of clozapine response. Here we evaluate these as well as other measures in an effort to find predictors of response to clozapine in our early-onset treatment-refractory population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0890-8567
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pubmed:author |
pubmed-author:BobbAaron JAJ,
pubmed-author:ClasenLiv SLS,
pubmed-author:GochmanPeter APA,
pubmed-author:GogtayNitinN,
pubmed-author:GreensteinDeanna KDK,
pubmed-author:LenaneMarge CMC,
pubmed-author:RapoportJudith LJL,
pubmed-author:SpencerEdgar PEP,
pubmed-author:SpornAlexandra LAL,
pubmed-author:StayerCatherine CCC,
pubmed-author:TossellJulia WJW,
pubmed-author:VermaniAnoopA
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1349-56
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pubmed:meshHeading |
pubmed-meshheading:17885577-Adolescent,
pubmed-meshheading:17885577-Age of Onset,
pubmed-meshheading:17885577-Antipsychotic Agents,
pubmed-meshheading:17885577-Brief Psychiatric Rating Scale,
pubmed-meshheading:17885577-Child,
pubmed-meshheading:17885577-Clozapine,
pubmed-meshheading:17885577-Double-Blind Method,
pubmed-meshheading:17885577-Drug Therapy,
pubmed-meshheading:17885577-Female,
pubmed-meshheading:17885577-Humans,
pubmed-meshheading:17885577-Male,
pubmed-meshheading:17885577-Schizophrenia, Childhood,
pubmed-meshheading:17885577-Time Factors,
pubmed-meshheading:17885577-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Clozapine treatment of childhood-onset schizophrenia: evaluation of effectiveness, adverse effects, and long-term outcome.
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pubmed:affiliation |
Child Psychiatry Branch, NIMH, Bethesda, MD, USA. als2168@columbia.edu
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, N.I.H., Intramural
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