|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007301,
umls-concept:C0017262,
umls-concept:C0026809,
umls-concept:C0033414,
umls-concept:C0181078,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0221928,
umls-concept:C0225336,
umls-concept:C0331858,
umls-concept:C0581603,
umls-concept:C0664336,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C2911684
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2007-11-5
|
|
pubmed:abstractText |
The present study examined the effects of cartilage oligometric matrix protein angiopoietin-1 (COMP-Ang1) on the revascularization of mice skin grafts. Full-thickness skin grafts were autotransferred into BALB/c mice. The donor grafts were soaked in COMP-Ang1 protein (50 mug/ml, n = 10) or in bovine serum albumin (BSA) (50 mug/ml, n = 10) dissolved in 1 ml of sterile, phosphate-buffered saline for 5 minutes before transfer. Revascularization of the grafts was monitored using an intravital microscope on postoperative days 3, 4, and 5. Morphological and immunohistochemical analyses were performed to evaluate platelet-endothelial cell adhesion molecule-1 and survivin expression and apoptotic signal in the transplanted grafts. Grafts soaked in COMP-Ang1 (COMP-Ang1 group) showed significantly increased revascularization compared with grafts soaked in BSA (BSA group) on intravital microscopy and platelet-endothelial cell adhesion molecule-1 staining. The COMP-Ang1 group showed a significant increase of survivin expression in the endothelial cells and a reduction of apoptotic signal in comparison to the BSA group. Therefore, we believe that COMP-Ang1 provides the therapeutic benefit of enhancing the survival of vascular endothelial cells during transplantation of skin graft.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-10218485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-10473668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-10611349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-10617467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-10653393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-10734041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-10738331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-11156885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-12682466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-15060279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-15060280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-15105657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-15161630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-15500640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-15851516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-15961719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-16525274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-16543381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-16885409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-2421814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-6253831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-8980224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-9226458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17884969-9989825
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0002-9440
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
171
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1682-90
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17884969-Animals,
pubmed-meshheading:17884969-Antigens, CD31,
pubmed-meshheading:17884969-Apoptosis,
pubmed-meshheading:17884969-Dermis,
pubmed-meshheading:17884969-Endothelial Cells,
pubmed-meshheading:17884969-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:17884969-Mice,
pubmed-meshheading:17884969-Mice, Inbred BALB C,
pubmed-meshheading:17884969-Microtubule-Associated Proteins,
pubmed-meshheading:17884969-Neovascularization, Physiologic,
pubmed-meshheading:17884969-Oxidative Stress,
pubmed-meshheading:17884969-Recombinant Fusion Proteins,
pubmed-meshheading:17884969-Repressor Proteins,
pubmed-meshheading:17884969-Skin Transplantation
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Cartilage oligometric matrix protein-angiopoietin-1 promotes revascularization through increased survivin expression in dermal endothelial cells of skin grafts in mice.
|
|
pubmed:affiliation |
Institute for Radiological Imaging Science, Wonkwang University School of Medicine, Jeonbuk, Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
