Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-9-21
pubmed:abstractText
Lead (Pb) may affect humoral and cellular immunity, acting on lymphocytes as well as on granulocytes and monocytes. Cytokines and nitric oxide (NO) play a central role in the immune balance. In this study, plasma levels of nitrites and nitrates (NOx), IL2, IL4, IL6, IL10, TNF-alpha and INF-gamma, were measured in healthy workers with very low (Pb-B=3.2-18.0 microg/dL) and low (Pb-B=9.1-46.0 microg/dL) Pb-exposure compared to non-exposed workers. Low Pb-exposed workers (Pb-B=9.1 -46.0 microg/ dL) were found to have significantly higher plasma IL-10 levels, and tendentially higher plasma TNF-alpha levels compared to non-exposed workers. This is the first report of a significant increase of plasma IL-10 levels in Pb-exposed workers. Plasma IL-10 increase was influenced by blood Pb levels even after correction for main confounding factors. No difference was found in plasma NOx levels between Pb-exposed and non-exposed workers, which is in agreement with previous findings exclusively regarding groups in the general population. Low Pb-exposure can induce an increase of pro-inflammatory cytokines, such as TNF-alpha, with a consequent increase of other cytokines, such as IL-10, considered a T cell cross-regulatory factor, suggesting possible interference of Pb in the system of immunophlogosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Heme, http://linkedlifedata.com/resource/pubmed/chemical/IL10 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/IL4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/IL6 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Lead, http://linkedlifedata.com/resource/pubmed/chemical/Nitrates, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitrites, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0960-3271
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
551-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17884957-Adult, pubmed-meshheading:17884957-Antibody Formation, pubmed-meshheading:17884957-Biological Markers, pubmed-meshheading:17884957-Cytokines, pubmed-meshheading:17884957-Heme, pubmed-meshheading:17884957-Humans, pubmed-meshheading:17884957-Immunity, Cellular, pubmed-meshheading:17884957-Interferon-gamma, pubmed-meshheading:17884957-Interleukin-10, pubmed-meshheading:17884957-Interleukin-2, pubmed-meshheading:17884957-Interleukin-4, pubmed-meshheading:17884957-Interleukin-6, pubmed-meshheading:17884957-Lead, pubmed-meshheading:17884957-Male, pubmed-meshheading:17884957-Metallurgy, pubmed-meshheading:17884957-Middle Aged, pubmed-meshheading:17884957-Nitrates, pubmed-meshheading:17884957-Nitric Oxide, pubmed-meshheading:17884957-Nitrites, pubmed-meshheading:17884957-Occupational Exposure, pubmed-meshheading:17884957-Tumor Necrosis Factor-alpha
pubmed:year
2007
pubmed:articleTitle
Effect of lead on the levels of some immunoregulatory cytokines in occupationally exposed workers.
pubmed:affiliation
Department of Molecular Pathology and Innovative Therapies, Clinic of Occupational Medicine, Polytechnic University of Marche, Ancona, Italy. m.valentino@univpm.it
pubmed:publicationType
Journal Article