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rdf:type |
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lifeskim:mentions |
umls-concept:C0001175,
umls-concept:C0012634,
umls-concept:C0020094,
umls-concept:C0030481,
umls-concept:C0030705,
umls-concept:C0037928,
umls-concept:C0039194,
umls-concept:C0076560,
umls-concept:C0147139,
umls-concept:C0205217,
umls-concept:C0231204,
umls-concept:C0279477,
umls-concept:C0332281,
umls-concept:C0376249,
umls-concept:C0449435,
umls-concept:C1143767,
umls-concept:C1332714,
umls-concept:C1336626,
umls-concept:C1439296,
umls-concept:C1442734,
umls-concept:C1533179,
umls-concept:C1704619,
umls-concept:C1882417
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pubmed:issue |
1-2
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pubmed:dateCreated |
2008-2-11
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pubmed:abstractText |
To investigate whether fractalkine receptor CX3CR1 polymorphisms that have been associated with rapid progression to AIDS among HIV-1 positive individuals also affects the risk of human T cell lymphotropic virus type 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP), we compared the allele frequencies of V249I and T280M between 233 HAM/TSP patients and 213 HTLV-1 seropositive asymptomatic carriers (HCs). Although the frequency and absolute number of peripheral blood CX3CR1+CD4+T cells were significantly increased in HAM/TSP patients compared to HCs and uninfected controls independent of HTLV-1 trans-activator protein Tax, we could not observe any association between the two polymorphisms and the risk of HAM/TSP in our cohort.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-510X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
266
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-9
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pubmed:meshHeading |
pubmed-meshheading:17884099-Alleles,
pubmed-meshheading:17884099-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17884099-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17884099-Carrier State,
pubmed-meshheading:17884099-Deltaretrovirus Antibodies,
pubmed-meshheading:17884099-Flow Cytometry,
pubmed-meshheading:17884099-Genotype,
pubmed-meshheading:17884099-HIV Infections,
pubmed-meshheading:17884099-Humans,
pubmed-meshheading:17884099-Lymphocyte Count,
pubmed-meshheading:17884099-Paraparesis, Tropical Spastic,
pubmed-meshheading:17884099-Polymorphism, Genetic,
pubmed-meshheading:17884099-Receptors, Chemokine,
pubmed-meshheading:17884099-Spinal Cord
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pubmed:year |
2008
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pubmed:articleTitle |
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease.
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pubmed:affiliation |
Department of Microbiology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa 920-0293, Japan. mineki@kanazawa-med.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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