rdf:type |
|
lifeskim:mentions |
umls-concept:C0001473,
umls-concept:C0005821,
umls-concept:C0011847,
umls-concept:C0017262,
umls-concept:C0185117,
umls-concept:C0205161,
umls-concept:C0205314,
umls-concept:C0522310,
umls-concept:C0596235,
umls-concept:C0679622,
umls-concept:C1519316,
umls-concept:C2911684
|
pubmed:issue |
10
|
pubmed:dateCreated |
2007-9-21
|
pubmed:abstractText |
Previous studies have shown platelet Ca(2+) abnormalities in diabetes mellitus and some reports suggest abnormal platelet production. Platelet Ca(2+) homeostasis is controlled by a multi-Ca(2+)-ATPase system that includes two plasma membrane Ca(2+)-ATPase (PMCA) and seven sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) isoforms. In addition, we recently found that the expression of PMCA4b and SERCA3 isoforms may serve as new markers of abnormal megakaryocytopoiesis [Nurden P et al. Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia. Blood 2006; 108: 2587-95].
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1538-7933
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2127-35
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:17883705-Adult,
pubmed-meshheading:17883705-Aged,
pubmed-meshheading:17883705-Blood Platelets,
pubmed-meshheading:17883705-Calcium-Transporting ATPases,
pubmed-meshheading:17883705-Diabetes Mellitus,
pubmed-meshheading:17883705-Female,
pubmed-meshheading:17883705-Fibrinolytic Agents,
pubmed-meshheading:17883705-Gene Expression Regulation,
pubmed-meshheading:17883705-Humans,
pubmed-meshheading:17883705-Male,
pubmed-meshheading:17883705-Megakaryocytes,
pubmed-meshheading:17883705-Middle Aged,
pubmed-meshheading:17883705-Pilot Projects,
pubmed-meshheading:17883705-Plasma Membrane Calcium-Transporting ATPases,
pubmed-meshheading:17883705-Sarcoplasmic Reticulum Calcium-Transporting ATPases,
pubmed-meshheading:17883705-Thrombopoiesis
|
pubmed:year |
2007
|
pubmed:articleTitle |
Platelet PMCA- and SERCA-type Ca2+ -ATPase expression in diabetes: a novel signature of abnormal megakaryocytopoiesis.
|
pubmed:affiliation |
U689 INSERM, CRCIL, Hôpital Lariboisière, Paris Cedex 10, France.
|
pubmed:publicationType |
Journal Article
|