Linked Life Data

17882653

Source:http://linkedlifedata.com/resource/pubmed/id/17882653

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-9-20
pubmed:abstractText
Adenosine has been observed to suppress the growth of MOLT-4 human leukemia cells in vitro. Changes in the cell cycle, especially increased percentage of cells in S phase, prolonged generation time, and induction of apoptosis at higher adenosine concentrations have been found to be responsible for the growth suppression. Dipyridamole, a drug inhibiting the cellular uptake of adenosine, reversed partially but significantly the adenosine-induced growth suppression. It follows from these results that the action of adenosine on the MOLT-4 cells comprises its cellular uptake and intracellular operation. These findings present new data on anticancer efficacy of adenosine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0735-7907
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-26
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Effect of adenosine on the growth of human T-lymphocyte leukemia cell line MOLT-4.
pubmed:affiliation
Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic. streitova@ibp.cz
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't