|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0031437,
umls-concept:C0178874,
umls-concept:C0185117,
umls-concept:C0392756,
umls-concept:C0580822,
umls-concept:C0664613,
umls-concept:C1319315,
umls-concept:C1332098,
umls-concept:C1547300,
umls-concept:C1548760,
umls-concept:C1550594,
umls-concept:C2911684
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2007-11-16
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|
pubmed:abstractText |
Apoptotic protease activating factor-1 (Apaf-1) is one of the key regulators in the mitochondrial apoptotic pathway, and the loss of Apaf-1 leads to cellular resistance against the apoptotic signals. We investigated the expression of Apaf-1 in colorectal tissues corresponding to the multistep carcinogenesis model to determine correlations between the clinicopathologic characteristics and the expression of this molecule and to evaluate the role of Apaf-1 in the development and progression of colorectal adenocarcinoma.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1534-4681
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3453-9
|
|
pubmed:meshHeading |
pubmed-meshheading:17882496-Adenocarcinoma,
pubmed-meshheading:17882496-Adenoma,
pubmed-meshheading:17882496-Adult,
pubmed-meshheading:17882496-Aged,
pubmed-meshheading:17882496-Aged, 80 and over,
pubmed-meshheading:17882496-Apoptotic Protease-Activating Factor 1,
pubmed-meshheading:17882496-Colorectal Neoplasms,
pubmed-meshheading:17882496-Disease Progression,
pubmed-meshheading:17882496-Female,
pubmed-meshheading:17882496-Humans,
pubmed-meshheading:17882496-Immunoenzyme Techniques,
pubmed-meshheading:17882496-Lymphatic Metastasis,
pubmed-meshheading:17882496-Male,
pubmed-meshheading:17882496-Middle Aged,
pubmed-meshheading:17882496-Neoplasm Staging,
pubmed-meshheading:17882496-Prognosis,
pubmed-meshheading:17882496-Retrospective Studies,
pubmed-meshheading:17882496-Survival Rate,
pubmed-meshheading:17882496-Tissue Array Analysis,
pubmed-meshheading:17882496-Tumor Markers, Biological
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Reduced expression of Apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype.
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|
pubmed:affiliation |
Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
