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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005953,
umls-concept:C0007786,
umls-concept:C0021308,
umls-concept:C0078058,
umls-concept:C0086022,
umls-concept:C0162597,
umls-concept:C0206679,
umls-concept:C0332161,
umls-concept:C0392756,
umls-concept:C0442335,
umls-concept:C0449468,
umls-concept:C0521654,
umls-concept:C1171892,
umls-concept:C1705099,
umls-concept:C1882598
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pubmed:issue |
3
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pubmed:dateCreated |
2007-9-20
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|
pubmed:abstractText |
Several reports recently suggested that vascular endothelial growth factor (VEGF) may have a therapeutic benefit against experimental cerebral infarction animal models. In addition, bone marrow stromal cells (BMSCs) are known to have therapeutic potency in improving neurological deficits after occlusive cerebrovascular diseases. In the present study, we evaluated the hypothesis that intracerebral transplantation of VEGF gene-transferred BMSCs could provide a greater therapeutic effect than intracerebral transplantation of native (non-gene-transformed) BMSCs by using a transient middle cerebral artery occlusion (MCAO) rat model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4040
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
586-94; discussion 594-5
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pubmed:meshHeading |
pubmed-meshheading:17881973-Animals,
pubmed-meshheading:17881973-Bone Marrow Transplantation,
pubmed-meshheading:17881973-Brain Ischemia,
pubmed-meshheading:17881973-Gene Transfer Techniques,
pubmed-meshheading:17881973-Genetic Engineering,
pubmed-meshheading:17881973-Genetic Vectors,
pubmed-meshheading:17881973-Herpesvirus 1, Human,
pubmed-meshheading:17881973-Humans,
pubmed-meshheading:17881973-Infarction, Middle Cerebral Artery,
pubmed-meshheading:17881973-Rats,
pubmed-meshheading:17881973-Rats, Wistar,
pubmed-meshheading:17881973-Stromal Cells,
pubmed-meshheading:17881973-Vascular Endothelial Growth Factor A
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pubmed:year |
2007
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pubmed:articleTitle |
Vascular endothelial growth factor gene-transferred bone marrow stromal cells engineered with a herpes simplex virus type 1 vector can improve neurological deficits and reduce infarction volume in rat brain ischemia.
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pubmed:affiliation |
Department of Neurosurgery, Osaka Medical College, Takatsuki City, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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