Source:http://linkedlifedata.com/resource/pubmed/id/17879743
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2007-9-20
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pubmed:abstractText |
The phytochemical analysis of the ethyl acetate fraction of Arum palaestinum Boiss. (Araceae) led to the isolation and identification of a new polyhydroxy alkaloid compound; (S)-3,4,5-trihydroxy-1 H-pyrrol-2(5H)-one (1), and other five known compounds; caffeic acid (2), isoorientin (3), luteolin (4) and vicenin 11 (5), as well as the rare compound 3,6,8-trimethoxy, 5,7,3',4'-tetrahydroxy flavone (6). The structural elucidations of all the compounds were based on spectroscopic data (1H- and 13C-NMR, DEPT, HSQC, HMBC and NOE difference techniques) and comparison with literature data. Investigation of the antioxidant activity of the ethyl acetate fraction indicated its strong scavenging capacity for 1,1 -diphenyl-2-picrylhydrazyl (DPPH) radicals (SC50 3.1+/-0.82 microg/mL). Moreover, the treatment of different human cancer cell lines with the ethyl acetate fraction led to dose-dependant suppression in the proliferation of both breast carcinoma cells (MCF-7; IC50 59.09+/-4.1 microg/mL) and lymphoblastic leukemia cells (1301; IC50 53.1+/-2.9 microg/mL); however, it was found to have no effect on the growth of hepatocellular carcinoma cells (Hep G2).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetates,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/ethyl acetate
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0253-6269
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
927-31
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pubmed:meshHeading |
pubmed-meshheading:17879743-Acetates,
pubmed-meshheading:17879743-Alkaloids,
pubmed-meshheading:17879743-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17879743-Arum,
pubmed-meshheading:17879743-Cell Line, Tumor,
pubmed-meshheading:17879743-Cell Proliferation,
pubmed-meshheading:17879743-Cell Survival,
pubmed-meshheading:17879743-Dose-Response Relationship, Drug,
pubmed-meshheading:17879743-Free Radical Scavengers,
pubmed-meshheading:17879743-Humans,
pubmed-meshheading:17879743-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17879743-Molecular Structure,
pubmed-meshheading:17879743-Plant Extracts,
pubmed-meshheading:17879743-Pyrroles
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pubmed:year |
2007
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pubmed:articleTitle |
A new pyrrole alkaloid isolated from Arum palaestinum Boiss. and its biological activities.
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pubmed:affiliation |
College of Forest Science, Kookmin University, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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