Linked Life Data

17879265

Source:http://linkedlifedata.com/resource/pubmed/id/17879265

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2007-9-27
pubmed:abstractText
Genetic variability in the alpha-synuclein gene and long-term exposure to the pesticide paraquat constitute possible risk factors for sporadic Parkinson's disease. The goal of the present study was to further characterize the effects of paraquat in mice as a model of Parkinson's disease and to determine whether it acted synergistically with alpha-synuclein over-expression to cause nigrostriatal cell death or dysfunction. Paraquat (10 mg/kg i.p.) was administered once a week for 3 weeks to mice over-expressing human alpha-synuclein under the Thy1 promoter and their wild-type littermates. The effect of paraquat on catecholaminergic neurons was reminiscent of that of Parkinson's disease, with preferential loss of dopaminergic neurons in the ventral tier of the substantia nigra pars compacta and loss of tyrosine hydroxylase staining in the locus coeruleus. alpha-Synuclein over-expression did not increase paraquat-induced cell loss, and paraquat did not worsen the behavioral deficits observed in the transgenic mice. However, paraquat markedly increased proteinase-K-resistant alpha-synuclein aggregates in substantia nigra of the transgenic mice. The data further validate the use of paraquat to model Parkinson's disease in mice and show that although paraquat and alpha-synuclein over-expression act synergistically to increase protein aggregation in vivo, this interaction does not result in short-term neuroprotection or increased vulnerability of nigrostriatal neurons.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-10473250, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-10877666, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-10934251, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-11193145, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-11445065, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-11532993, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-11701929, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-11707429, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-12111846, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-12127150, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-12143362, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-12428721, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-12498954, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-12541013, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-12716914, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-1353337, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15009131, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15155938, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15455394, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15474350, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15483602, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15496679, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15649693, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15728853, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15790533, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15834418, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15857406, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-15890009, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-1620342, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-16677770, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-16713278, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-16837598, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-1690789, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-16934409, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-17015225, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-17078043, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-17166727, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-17255333, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-1793176, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-1933245, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-1958262, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-1972319, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-2305814, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-3259295, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-6147127, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-78748, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-9117542, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-9130677, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-9191770, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-9351666, http://linkedlifedata.com/resource/pubmed/commentcorrection/17879265-9778247
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0887-4476
pubmed:author
pubmed:copyrightInfo
(c) 2007 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
991-1001
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
More...