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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-9-19
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pubmed:abstractText |
Evolutionary theory predicts that organisms should evolve the ability to produce high fitness phenotypes in the face of environmental disturbances (environmental robustness) or genetic mutations (genetic robustness). While several studies have uncovered mechanisms that lead to both environmental and genetic robustness, we have yet to understand why some components of the genome are more robust than others. According to evolutionary theory, environmental and genetic robustness will have different responses to selective forces. Selection on environmental robustness for a trait is expected to be strong and related to the fitness costs of altering that trait. In contrast to environmental robustness, selection on genetic robustness for a trait is expected to be largely independent of the fitness cost of altering the trait and instead should correlate with the standing genetic variation for the trait that can potentially be buffered. Several mechanisms that provide both environmental and genetic robustness have been described, and this correlation could be explained by direct selection on both forms of robustness (direct selection hypothesis), or through selection on environmental robustness and a correlated response in genetic robustness (congruence hypothesis).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-10440723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-10655498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-10688190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-10910359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-10929718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-10937177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-11069142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-11102521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-11283351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-11382364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-11805826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-11805837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-11875207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-12140549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-12149521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-12399584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-12620108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-12748633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-14575319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-14690591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-14759368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-15238511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-15616139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-16250465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-16699522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-16701391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-17017054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-9202124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-9207794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17878946-9845070
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e911
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pubmed:meshHeading |
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pubmed:year |
2007
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pubmed:articleTitle |
Direct selection on genetic robustness revealed in the yeast transcriptome.
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pubmed:affiliation |
Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, Iowa, United States of America. proulx@iastate.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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