Linked Life Data

17877111

Source:http://linkedlifedata.com/resource/pubmed/id/17877111

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2007-9-19
pubmed:abstractText
The bacterial product CANTASTIM (CS) is a purified extract of Pseudomonas aeruginosa that induces non-specific protection against bacterial infection, enhances macrophage effector functions and modulates production of cytokines. Most likely, it interacts with components of the innate immune response. Cytokine production can be used to assess the bioactivity of this product but these biomolecules operate in vivo in a complex regulatory network with reciprocal influences so there is a need for profiling an array of cytokines rather than an individual analysis. Current technology development of multiplex immunoassay for simultaneous measurement of multiple analytes in a single assay has greatly improved the throughput and cost effectiveness of cytokine profiling and proved to be an effective approach to evaluate the immunomodulatory activity of the bacterial product CS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1222-3891
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-8
pubmed:meshHeading
pubmed:articleTitle
Cytokine profiling by multiplex immunoassay as an effective approach to assess immunomodulatory activity of bacterial product CANTASTIM.
pubmed:affiliation
Infection and Immunity Laboratory, "Cantacuzino" National Institute of Research and Development for Microbiology and Immunology, Bucharest, Romania. llerescu@cantacuzino.ro
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't