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rdf:type |
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lifeskim:mentions |
umls-concept:C0015350,
umls-concept:C0016059,
umls-concept:C0021853,
umls-concept:C0034693,
umls-concept:C0085542,
umls-concept:C0086418,
umls-concept:C0332161,
umls-concept:C1412517,
umls-concept:C1413791,
umls-concept:C1423613,
umls-concept:C1707310,
umls-concept:C1720675
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pubmed:issue |
18 Pt 1
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pubmed:dateCreated |
2007-9-18
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pubmed:abstractText |
Purposes: Intestinal complications after radiotherapy are caused by transmural fibrosis and impair the quality of life of cancer survivors. Radiation fibrosis was considered permanent and irreversible, but recently, its dynamic nature was shown, providing new opportunities for the development of antifibrotic therapies. Among these new targets, we identified the Rho/ROCK pathway and thought to investigate whether pravastatin treatment inhibits Rho pathway activation and elicits an antifibrotic action.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTGF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Ctgf protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Pravastatin,
http://linkedlifedata.com/resource/pubmed/chemical/rho GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rho-Associated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5331-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17875761-Animals,
pubmed-meshheading:17875761-Connective Tissue Growth Factor,
pubmed-meshheading:17875761-Extracellular Matrix,
pubmed-meshheading:17875761-Fibrosis,
pubmed-meshheading:17875761-Humans,
pubmed-meshheading:17875761-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:17875761-Immediate-Early Proteins,
pubmed-meshheading:17875761-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:17875761-Intestinal Diseases,
pubmed-meshheading:17875761-Intestines,
pubmed-meshheading:17875761-Male,
pubmed-meshheading:17875761-Pravastatin,
pubmed-meshheading:17875761-Radiation Injuries,
pubmed-meshheading:17875761-Rats,
pubmed-meshheading:17875761-Rats, Wistar,
pubmed-meshheading:17875761-rho GTP-Binding Proteins,
pubmed-meshheading:17875761-rho-Associated Kinases
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pubmed:year |
2007
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pubmed:articleTitle |
Pravastatin Inhibits the Rho/CCN2/extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats.
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pubmed:affiliation |
UPRES EA 27-10 Radiosensibilité des Tumeurs et Tissus Sains, Institut de Radioprotection et de Sûreté Nucléaire/Institut Gustave Roussy, Villejuif, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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