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rdf:type |
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lifeskim:mentions |
umls-concept:C0002198,
umls-concept:C0003873,
umls-concept:C0025677,
umls-concept:C0030705,
umls-concept:C0063041,
umls-concept:C0229671,
umls-concept:C0392756,
umls-concept:C0441889,
umls-concept:C0623362,
umls-concept:C1704241,
umls-concept:C1879547
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-13
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pubmed:abstractText |
To analyse the effects of leflunomide and methotrexate treatment on matrix metalloproteinase (MMP) activity levels in alpha2 macroglobulin/MMP (alpha2M/MMP) complexes in the systemic circulation of rheumatoid arthritis (RA) patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antirheumatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate,
http://linkedlifedata.com/resource/pubmed/chemical/Multiprotein Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylalanine,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Macroglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/batimastat,
http://linkedlifedata.com/resource/pubmed/chemical/leflunomide
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1468-2060
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
128-30
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pubmed:meshHeading |
pubmed-meshheading:17875551-Aged,
pubmed-meshheading:17875551-Antirheumatic Agents,
pubmed-meshheading:17875551-Arthritis, Rheumatoid,
pubmed-meshheading:17875551-Biological Markers,
pubmed-meshheading:17875551-C-Reactive Protein,
pubmed-meshheading:17875551-Down-Regulation,
pubmed-meshheading:17875551-Enzyme Inhibitors,
pubmed-meshheading:17875551-Female,
pubmed-meshheading:17875551-Humans,
pubmed-meshheading:17875551-Isoxazoles,
pubmed-meshheading:17875551-Male,
pubmed-meshheading:17875551-Matrix Metalloproteinases,
pubmed-meshheading:17875551-Methotrexate,
pubmed-meshheading:17875551-Middle Aged,
pubmed-meshheading:17875551-Multiprotein Complexes,
pubmed-meshheading:17875551-Phenylalanine,
pubmed-meshheading:17875551-Statistics, Nonparametric,
pubmed-meshheading:17875551-Thiophenes,
pubmed-meshheading:17875551-alpha-Macroglobulins
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pubmed:year |
2008
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pubmed:articleTitle |
Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients.
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pubmed:affiliation |
Leiden University Medical Centre, Leiden, Location C4R-70, The Netherlands. I.Tchetverikov@lumc.nl
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Multicenter Study
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