Source:http://linkedlifedata.com/resource/pubmed/id/17875505
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2007-9-18
|
| pubmed:abstractText |
Burkitt lymphoma (BL) is characterized by c-myc translocation and CD10+/bc-2-/bcl-6+ with a very high Ki-67 proliferation index (PI). Occasional diffuse large B-cell lymphomas may exhibit a very high PI with or without a starry-sky pattern (DLBCL-HPSS). We compared 28 consecutive BL and 16 DLBCL-HPSS cases in immunocompetent Taiwanese diagnosed by histopathologic examination and immunophenotyping and compared the results with results for Epstein-Barr virus-encoded messenger RNA (EBER) and fluorescence in situ hybridization (FISH). There were statistically significant differences in the expression of CD10 (28/28 vs 1/16), bcl-2 (3/28 vs 11/16), MUM1 (5/28 vs 15/16), a PI of 95.0% or more (27/28 vs 2/16), and combined CD10+/bcl-2-/bcl-6+ (24/28 vs 1/16) between BLs and DLBCL-HPSSs. Of the BLs, 7 (25%) of 28 and 26 (96%) of 27 were positive for EBER and c-myc rearrangement as compared with 0 of 16 and 1 (7%) of 15 DLBCL-HPSSs, respectively. We can confidently distinguish BL from DLBCL-HPSS by using histopathologic and immunohistochemical (CD10, bcl-2, bcl-6, Ki-67) methods without the aid of EBER and FISH in the great majority of cases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0002-9173
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
128
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
558-64
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:17875505-Adolescent,
pubmed-meshheading:17875505-Adult,
pubmed-meshheading:17875505-Aged,
pubmed-meshheading:17875505-Burkitt Lymphoma,
pubmed-meshheading:17875505-Cell Proliferation,
pubmed-meshheading:17875505-Child,
pubmed-meshheading:17875505-Child, Preschool,
pubmed-meshheading:17875505-Diagnosis, Differential,
pubmed-meshheading:17875505-Female,
pubmed-meshheading:17875505-Herpesvirus 4, Human,
pubmed-meshheading:17875505-Humans,
pubmed-meshheading:17875505-Immunophenotyping,
pubmed-meshheading:17875505-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17875505-Infant,
pubmed-meshheading:17875505-Lymphoma, B-Cell,
pubmed-meshheading:17875505-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:17875505-Male,
pubmed-meshheading:17875505-Middle Aged,
pubmed-meshheading:17875505-RNA, Viral,
pubmed-meshheading:17875505-Tumor Markers, Biological
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Histopathology and immunohistochemistry in distinguishing Burkitt lymphoma from diffuse large B-cell lymphoma with very high proliferation index and with or without a starry-sky pattern: a comparative study with EBER and FISH.
|
| pubmed:affiliation |
Department of Pathology, Chi-Mei Medical Center, Tainan Departments of Pathology, Taipei Medical University, Taipei, Taiwan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|