rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
2007-9-17
|
pubmed:abstractText |
To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0770-3198
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
26
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1675-8
|
pubmed:meshHeading |
pubmed-meshheading:17874259-Adult,
pubmed-meshheading:17874259-Estrogen Receptor alpha,
pubmed-meshheading:17874259-Estrogen Receptor beta,
pubmed-meshheading:17874259-Estrogens,
pubmed-meshheading:17874259-Female,
pubmed-meshheading:17874259-Gonadal Steroid Hormones,
pubmed-meshheading:17874259-Humans,
pubmed-meshheading:17874259-Leukocytes, Mononuclear,
pubmed-meshheading:17874259-Lupus Erythematosus, Systemic,
pubmed-meshheading:17874259-Male,
pubmed-meshheading:17874259-Middle Aged,
pubmed-meshheading:17874259-RNA, Messenger,
pubmed-meshheading:17874259-Receptors, Estrogen,
pubmed-meshheading:17874259-Sex Factors
|
pubmed:year |
2007
|
pubmed:articleTitle |
Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus.
|
pubmed:affiliation |
Department of General Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|