Linked Life Data

17874047

Source:http://linkedlifedata.com/resource/pubmed/id/17874047

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-9-17
pubmed:abstractText
The pathogenesis of corticosteroid-induced femoral head necrosis is assumed to be related to lipid metabolism. Mature fat cells are believed to play a central role in lipid metabolism. The purpose of this study was to investigate the size of mature fat cells in the human femoral head after steroid treatment. Cancerous bone tissue was obtained from the femoral heads of 20 women who had undergone total hip arthroplasty. This bone tissue was subsequently incubated in a medium containing 10(-7) or 10(-5) M dexamethasone for 5 days. Mature fat cells from the bone marrow were observed by scanning electron microscopy, and the largest diameter of individual fat cells was measured. The size of the mature fat cells in human bone marrow increased after high-dose steroid treatment. The largest fat cell volume after steroid treatment was one and one-half times larger than that observed in the control. Steroid-induced osteonecrosis is known to sometimes occur after high-dose steroid treatment. These findings may indicate the pathogenetic factors in the early stage of steroid-induced osteonecrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1860-1480
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
150-6
pubmed:dateRevised
2008-3-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Effects of glucocorticoid on adipocyte size in human bone marrow.
pubmed:affiliation
Department of Orthopaedic Surgery, Saga University Hospital, Saga University, 5-1-1 Nabeshima, Saga-shi, Saga 849-8501, Japan. urasam0905@yahoo.co.jp
pubmed:publicationType
Journal Article