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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-11-28
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pubmed:abstractText |
Accumulation of eosinophils in the bronchial mucosa of individuals with asthma is considered to be a central event in the pathogenesis of asthma. In animal models, airway eosinophil recruitment and airway hyperresponsiveness in response to allergen challenge are reduced by specific targeting of interleukin-5. A previous small dose-finding study found that mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, had no effect on allergen challenge in humans.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1535-4970
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pubmed:author |
pubmed-author:BarnesNeil CNC,
pubmed-author:BrannickLesleyL,
pubmed-author:BusseWilliamW,
pubmed-author:FaifermanIsidoreI,
pubmed-author:Flood-PagePatrickP,
pubmed-author:HanselTrevor TTT,
pubmed-author:International Mepolizumab Study Group,
pubmed-author:MatthewsJohnJ,
pubmed-author:RobinsonDouglasD,
pubmed-author:SwensonCheriC,
pubmed-author:WenzelSallyS,
pubmed-author:WilliamsMichaelM
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1062-71
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17872493-Administration, Inhalation,
pubmed-meshheading:17872493-Adrenergic Agonists,
pubmed-meshheading:17872493-Adrenergic beta-2 Receptor Agonists,
pubmed-meshheading:17872493-Adult,
pubmed-meshheading:17872493-Anti-Asthmatic Agents,
pubmed-meshheading:17872493-Antibodies, Monoclonal,
pubmed-meshheading:17872493-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:17872493-Asthma,
pubmed-meshheading:17872493-Beclomethasone,
pubmed-meshheading:17872493-Dose-Response Relationship, Drug,
pubmed-meshheading:17872493-Double-Blind Method,
pubmed-meshheading:17872493-Eosinophils,
pubmed-meshheading:17872493-Female,
pubmed-meshheading:17872493-Forced Expiratory Volume,
pubmed-meshheading:17872493-Humans,
pubmed-meshheading:17872493-Injections, Intravenous,
pubmed-meshheading:17872493-Male,
pubmed-meshheading:17872493-Middle Aged,
pubmed-meshheading:17872493-Peak Expiratory Flow Rate,
pubmed-meshheading:17872493-Quality of Life,
pubmed-meshheading:17872493-Severity of Illness Index,
pubmed-meshheading:17872493-Sputum,
pubmed-meshheading:17872493-Treatment Failure
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pubmed:year |
2007
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pubmed:articleTitle |
A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma.
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pubmed:affiliation |
F.R.C.P., London Chest Hospital, Bonner Road, London E2 9JX, UK.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Multicenter Study
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