|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5844
|
|
pubmed:dateCreated |
2007-9-17
|
|
pubmed:abstractText |
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report a dominant-negative TLR3 allele in otherwise healthy children with herpes simplex virus 1 (HSV-1) encephalitis. TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1095-9203
|
|
pubmed:author |
pubmed-author:AbelLaurentL,
pubmed-author:BarreiroLuisL,
pubmed-author:CasanovaJean-LaurentJL,
pubmed-author:CasrougeArmandaA,
pubmed-author:ChapgierArianeA,
pubmed-author:CognetCélineC,
pubmed-author:ElainGaëlleG,
pubmed-author:GeissmannFrédéricF,
pubmed-author:HéronBénédicteB,
pubmed-author:HamiltonClaireC,
pubmed-author:HovnanianAlainA,
pubmed-author:JouanguyEmmanuelleE,
pubmed-author:KuCheng-LungCL,
pubmed-author:LebonPierreP,
pubmed-author:LeonardJoshuaJ,
pubmed-author:LorenzoLazaroL,
pubmed-author:PicardCapucineC,
pubmed-author:PlancoulaineSabineS,
pubmed-author:PuelAnneA,
pubmed-author:Quintana-MurciLluisL,
pubmed-author:RomeroPedroP,
pubmed-author:RozenbergFloreF,
pubmed-author:Sancho-ShimizuVanessaV,
pubmed-author:SegalDavidD,
pubmed-author:SmahiAsmaA,
pubmed-author:TardieuMarcM,
pubmed-author:TiteuxMatthiasM,
pubmed-author:UgoliniSophieS,
pubmed-author:ValléeLouisL,
pubmed-author:VivierEricE,
pubmed-author:ZhangShen-YingSY,
pubmed-author:ZhangXin-XinXX,
pubmed-author:von BernuthHorstH
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
14
|
|
pubmed:volume |
317
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1522-7
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:17872438-Alleles,
pubmed-meshheading:17872438-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17872438-Cell Line,
pubmed-meshheading:17872438-Child, Preschool,
pubmed-meshheading:17872438-Dendritic Cells,
pubmed-meshheading:17872438-Encephalitis, Herpes Simplex,
pubmed-meshheading:17872438-Female,
pubmed-meshheading:17872438-Fibroblasts,
pubmed-meshheading:17872438-Genes, Dominant,
pubmed-meshheading:17872438-Herpesvirus 1, Human,
pubmed-meshheading:17872438-Heterozygote,
pubmed-meshheading:17872438-Humans,
pubmed-meshheading:17872438-Immunity, Innate,
pubmed-meshheading:17872438-Infant,
pubmed-meshheading:17872438-Interferons,
pubmed-meshheading:17872438-Keratinocytes,
pubmed-meshheading:17872438-Killer Cells, Natural,
pubmed-meshheading:17872438-Leukocytes, Mononuclear,
pubmed-meshheading:17872438-Mutation,
pubmed-meshheading:17872438-Poly I-C,
pubmed-meshheading:17872438-Toll-Like Receptor 3
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
TLR3 deficiency in patients with herpes simplex encephalitis.
|
|
pubmed:affiliation |
Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale (INSERM), U550, Faculty Necker, Paris 75015, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
