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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2007-10-22
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pubmed:abstractText |
A variety of tropane derivatives 14a-g were prepared via the reaction of the alcohol analogs 12a and 12b with substituted fluorobenzenes 13a-f. The prepared compounds were tested for their activity and selectivity toward the norepinephrine transporter (NET) and serotonin transporter (SERT) using yohimbine-induced mortality and 5-hydroxytryptophan-induced neurotoxicity in mice, respectively. All the tested compounds were found to be NE and 5-HT reuptake inhibitors except 14d which exhibited selective 5-HT reuptake inhibition activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-Hydroxytryptophan,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Citalopram,
http://linkedlifedata.com/resource/pubmed/chemical/Clomipramine,
http://linkedlifedata.com/resource/pubmed/chemical/Fluoxetine,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Tropanes,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7765-72
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pubmed:meshHeading |
pubmed-meshheading:17870537-5-Hydroxytryptophan,
pubmed-meshheading:17870537-Adrenergic alpha-Antagonists,
pubmed-meshheading:17870537-Animals,
pubmed-meshheading:17870537-Citalopram,
pubmed-meshheading:17870537-Clomipramine,
pubmed-meshheading:17870537-Crystallography, X-Ray,
pubmed-meshheading:17870537-Dose-Response Relationship, Drug,
pubmed-meshheading:17870537-Drug Evaluation, Preclinical,
pubmed-meshheading:17870537-Fluoxetine,
pubmed-meshheading:17870537-Mice,
pubmed-meshheading:17870537-Molecular Structure,
pubmed-meshheading:17870537-Norepinephrine,
pubmed-meshheading:17870537-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:17870537-Serotonin,
pubmed-meshheading:17870537-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:17870537-Serotonin Uptake Inhibitors,
pubmed-meshheading:17870537-Tropanes,
pubmed-meshheading:17870537-Yohimbine
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis of some tropane derivatives of anticipated activity on the reuptake of norepinephrine and/or serotonin.
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pubmed:affiliation |
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
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pubmed:publicationType |
Journal Article
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