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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-17
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pubmed:abstractText |
The Gram-positive pathogen Group B Streptococcus (GBS) is the leading cause of bacterial pneumonia, sepsis, and meningitis in human newborns. GBS elaborates a pore-forming toxin known as CAMP factor that synergizes with Staphylococcus aureus beta-toxin, generating a co-hemolytic reaction useful in identification of GBS in the clinical laboratory. To evaluate the indirect evidence implicating CAMP factor in GBS pathogenesis, the cfb gene encoding the pore-forming cytotoxin was deleted by precise allelic replacement. The virulence properties of the CAMP factor mutant were then explored by a series of in vitro and in vivo assays. Compared to wild-type, the isogenic GBS Deltacfb mutant demonstrated equivalent phagocyte resistance and endothelial cell invasiveness and also retained full virulence in a mouse model of infection. Our data suggest that CAMP factor expressed in its native context is not essential for systemic virulence of GBS.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-10456923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-11719807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-11807693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-12562790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-12835325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-12952922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-15263085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-15381763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-15554966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-15659687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-15870447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-16138192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-16773378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-17005013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-17086430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-2659534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-3042457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-3055197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-3294187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-3308308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-3546580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-7014603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17870297-8745004
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0882-4010
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-8
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:17870297-Animals,
pubmed-meshheading:17870297-Antimicrobial Cationic Peptides,
pubmed-meshheading:17870297-Bacterial Proteins,
pubmed-meshheading:17870297-Cathelicidins,
pubmed-meshheading:17870297-Genetic Complementation Test,
pubmed-meshheading:17870297-Hemolysin Proteins,
pubmed-meshheading:17870297-Humans,
pubmed-meshheading:17870297-Macrophages,
pubmed-meshheading:17870297-Mice,
pubmed-meshheading:17870297-Mice, Inbred C57BL,
pubmed-meshheading:17870297-Mutagenesis, Site-Directed,
pubmed-meshheading:17870297-Mutation,
pubmed-meshheading:17870297-Phenotype,
pubmed-meshheading:17870297-Streptococcal Infections,
pubmed-meshheading:17870297-Streptococcus agalactiae,
pubmed-meshheading:17870297-Survival Analysis,
pubmed-meshheading:17870297-Time Factors,
pubmed-meshheading:17870297-Virulence
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pubmed:year |
2008
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pubmed:articleTitle |
CAMP factor is not essential for systemic virulence of Group B Streptococcus.
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pubmed:affiliation |
Division of Pediatric Pharmacology and Drug Discovery, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0687, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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