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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-2-12
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pubmed:abstractText |
Hypermethylation of the reelin (RELN) promoter region and the reduced levels of its messenger RNA and protein have been implicated in the pathophysiology of schizophrenia. We intended a technical replication of recent studies that observed hypermethylation of CpG or CpNpG sites in the RELN promoter region in the brain of schizophrenic patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1873-2402
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17870056-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:17870056-DNA Methylation,
pubmed-meshheading:17870056-Epigenesis, Genetic,
pubmed-meshheading:17870056-Extracellular Matrix Proteins,
pubmed-meshheading:17870056-Humans,
pubmed-meshheading:17870056-Nerve Tissue Proteins,
pubmed-meshheading:17870056-Polymerase Chain Reaction,
pubmed-meshheading:17870056-Prefrontal Cortex,
pubmed-meshheading:17870056-Promoter Regions, Genetic,
pubmed-meshheading:17870056-RNA, Messenger,
pubmed-meshheading:17870056-Schizophrenia,
pubmed-meshheading:17870056-Sequence Analysis, DNA,
pubmed-meshheading:17870056-Serine Endopeptidases
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pubmed:year |
2008
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pubmed:articleTitle |
Methylation status of the reelin promoter region in the brain of schizophrenic patients.
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pubmed:affiliation |
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.
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pubmed:publicationType |
Journal Article
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