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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2007-10-15
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pubmed:abstractText |
We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7426-33
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pubmed:meshHeading |
pubmed-meshheading:17869123-Adenosine,
pubmed-meshheading:17869123-Binding Sites,
pubmed-meshheading:17869123-Breast Neoplasms,
pubmed-meshheading:17869123-Cell Line, Tumor,
pubmed-meshheading:17869123-Cell Proliferation,
pubmed-meshheading:17869123-Circular Dichroism,
pubmed-meshheading:17869123-DNA,
pubmed-meshheading:17869123-Dose-Response Relationship, Drug,
pubmed-meshheading:17869123-Drug Screening Assays, Antitumor,
pubmed-meshheading:17869123-Humans,
pubmed-meshheading:17869123-Molecular Structure,
pubmed-meshheading:17869123-Polyamines,
pubmed-meshheading:17869123-Structure-Activity Relationship,
pubmed-meshheading:17869123-Temperature,
pubmed-meshheading:17869123-Tumor Cells, Cultured,
pubmed-meshheading:17869123-Uridine
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pubmed:year |
2007
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pubmed:articleTitle |
Construction of polyamine-modified uridine and adenosine derivatives--evaluation of DNA binding capacity and cytotoxicity in vitro.
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pubmed:affiliation |
Organic Chemistry, Chemical Center, Lund Univesity, PO Box 124, SE-22100 Lund, Sweden.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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