Source:http://linkedlifedata.com/resource/pubmed/id/17869038
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2007-10-15
|
| pubmed:abstractText |
The aim of this study was to screen for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala Koidz. The rhizomes of Atractylodes macrocephala were treated with supercritical CO(2) fluid and the extract was separated by normal-phase and reverse-phase column chromatography. The separated samples were screened with white blood cell membrane (WBCM) chromatography (WBCM-C). The anti-inflammatory effects of these fractions and components were tested pharmacologically in vivo. The results indicated that the retention characteristics of the petrol-ether (1:1, v/v) fraction (BZC-2) of the supercritical CO(2) extract, the atractylenolide I and 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4, 6-diyn-1-ol isolated from BZC-2 as active fractions and components were similar to that of dexamethasone in WBCM-C. Therefore, they may act on WBCM and its receptors. BZC-2 has shown anti-inflammatory effects in acute and chronic inflammation models in rats and mice. Oral administration of atractylenolide I and 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol produced significant anti-inflammatory effects in acute and chronic inflammation models in mice. The screening results with WBCM-C were correlated significantly with pharmacological effects in vivo. Atractylenolide I and 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol were the main components of Atractylodes macrocephala that were effective as anti-inflammatory agents.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0378-8741
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
212-7
|
| pubmed:meshHeading |
pubmed-meshheading:17869038-Acetic Acid,
pubmed-meshheading:17869038-Animals,
pubmed-meshheading:17869038-Anti-Inflammatory Agents,
pubmed-meshheading:17869038-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:17869038-Atractylodes,
pubmed-meshheading:17869038-Capillary Permeability,
pubmed-meshheading:17869038-Carrageenan,
pubmed-meshheading:17869038-Cell Membrane,
pubmed-meshheading:17869038-Chromatography,
pubmed-meshheading:17869038-Cotton Fiber,
pubmed-meshheading:17869038-Dexamethasone,
pubmed-meshheading:17869038-Drug Evaluation, Preclinical,
pubmed-meshheading:17869038-Edema,
pubmed-meshheading:17869038-Female,
pubmed-meshheading:17869038-Granuloma,
pubmed-meshheading:17869038-Leukocytes,
pubmed-meshheading:17869038-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17869038-Male,
pubmed-meshheading:17869038-Plant Extracts,
pubmed-meshheading:17869038-Plant Roots,
pubmed-meshheading:17869038-Rabbits
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz.
|
| pubmed:affiliation |
School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
|
| pubmed:publicationType |
Journal Article
|