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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-21
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pubmed:abstractText |
Non-alcoholic fatty liver disease is the result of an imbalance in hepatic lipid partitioning that favors fatty acid synthesis and storage over fatty acid oxidation and triglyceride secretion. The progressive, inflammatory disorder of steatohepatitis can be prevented or reversed by correcting this lipid imbalance by activating peroxisome proliferator-activated receptor (PPAR) alpha, a transcription factor which regulates fatty acid oxidation. n-3 polyunsaturated fatty acids (PUFA), such as those found in fish oil (FO), are naturally occurring PPARalpha ligands which also suppress lipid synthesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1440-1746
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-75
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pubmed:meshHeading |
pubmed-meshheading:17868330-Animals,
pubmed-meshheading:17868330-Choline Deficiency,
pubmed-meshheading:17868330-Dietary Fats, Unsaturated,
pubmed-meshheading:17868330-Disease Models, Animal,
pubmed-meshheading:17868330-Down-Regulation,
pubmed-meshheading:17868330-Fatty Acids,
pubmed-meshheading:17868330-Fatty Acids, Omega-3,
pubmed-meshheading:17868330-Fatty Liver,
pubmed-meshheading:17868330-Female,
pubmed-meshheading:17868330-Fish Oils,
pubmed-meshheading:17868330-Gene Expression,
pubmed-meshheading:17868330-Lipid Peroxides,
pubmed-meshheading:17868330-Lipogenesis,
pubmed-meshheading:17868330-Lipolysis,
pubmed-meshheading:17868330-Liver,
pubmed-meshheading:17868330-Methionine,
pubmed-meshheading:17868330-Mice,
pubmed-meshheading:17868330-Mice, Inbred C57BL,
pubmed-meshheading:17868330-PPAR alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation.
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pubmed:affiliation |
Australian National University Medical School at The Canberra Hospital, Canberra, Australian Capital Territory, Australia. claire.larter@anu.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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