Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1992-3-23
pubmed:abstractText
The effects of long-term administration of opioid agonists on the regulation of prodynorphin gene expression in rat brain were investigated. Chronic intracerebroventricular treatment with the synthetic opioid agonist acting on the kappa receptor, U-50,488H, and the classic mu agonist morphine markedly decreased prodynorphin mRNA levels in hypothalamus, hippocampus and striatum of tolerant rats. Levels of ir-Dynorphin A remained unchanged except in two cases. Chronic exposure to opiates thus appears to induce modifications of the endogenous opioid system, as regards gene expression regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
563
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
132-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1786525-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benz..., pubmed-meshheading:1786525-Analgesics, pubmed-meshheading:1786525-Animals, pubmed-meshheading:1786525-Blotting, Northern, pubmed-meshheading:1786525-Brain Chemistry, pubmed-meshheading:1786525-Corpus Striatum, pubmed-meshheading:1786525-DNA Probes, pubmed-meshheading:1786525-Down-Regulation, pubmed-meshheading:1786525-Enkephalins, pubmed-meshheading:1786525-Gene Expression Regulation, pubmed-meshheading:1786525-Hippocampus, pubmed-meshheading:1786525-Hypothalamus, pubmed-meshheading:1786525-Male, pubmed-meshheading:1786525-Morphine, pubmed-meshheading:1786525-Narcotics, pubmed-meshheading:1786525-Protein Precursors, pubmed-meshheading:1786525-Pyrrolidines, pubmed-meshheading:1786525-RNA, Messenger, pubmed-meshheading:1786525-Rats, pubmed-meshheading:1786525-Rats, Inbred Strains
pubmed:year
1991
pubmed:articleTitle
Chronic opiate agonists down-regulate prodynorphin gene expression in rat brain.
pubmed:affiliation
Department of Pharmacology, University of Bologna, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't