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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1992-3-20
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pubmed:abstractText |
A significant number of intraepithelial intestinal T cells appear to mature extrathymically. In this paper, Leo Lefrançois discusses the implication of this for T-cell receptor selection and repertoire generation. He goes on to develop the concept that such cells may constitute discrete subsets of organ-specific lymphocytes, with unique T-cell receptor repertoires that may be evolutionary antecedents of thymus-derived T cells.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0167-5699
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
436-8
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pubmed:dateRevised |
2005-11-16
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pubmed:meshHeading |
pubmed-meshheading:1786079-Animals,
pubmed-meshheading:1786079-Antigens, CD8,
pubmed-meshheading:1786079-Autoimmune Diseases,
pubmed-meshheading:1786079-Bone Marrow Transplantation,
pubmed-meshheading:1786079-Cell Differentiation,
pubmed-meshheading:1786079-Epithelial Cells,
pubmed-meshheading:1786079-Epithelium,
pubmed-meshheading:1786079-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:1786079-Immune Tolerance,
pubmed-meshheading:1786079-Intestinal Mucosa,
pubmed-meshheading:1786079-Intestine, Small,
pubmed-meshheading:1786079-Mice,
pubmed-meshheading:1786079-Mice, Nude,
pubmed-meshheading:1786079-Radiation Chimera,
pubmed-meshheading:1786079-Receptors, Antigen, T-Cell,
pubmed-meshheading:1786079-T-Lymphocyte Subsets
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pubmed:year |
1991
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pubmed:articleTitle |
Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?
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pubmed:affiliation |
Dept of Cell Biology, Upjohn Company, Kalamazoo, MI 49001.
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pubmed:publicationType |
Journal Article,
Review
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