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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1976-8-2
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pubmed:abstractText |
Murine and hamster cell lines, each transformed with a different strain of herpes simplex virus (HSV), were examined for cross-reacting antigens by in vitro and in vivo assays. A comparative study by the indirect immunofluorescence technique detected common cross-reacting viral antigens. Cytoplasmic fluorescence patterns were observed in the 333-8-9 hamster line, the H238 murine line, and the H238 clonal lines; these patterns were identical to the fluorescence pattern of HSV -2-infected controls when reacted with HSV antiserum. Tumor rejection studies in the BALB/c host indicated that each cell line provided immunity against a tumorigenic challenge of transformed mouse cells. The H238 clone EC1 3 provided a 53% immunity against itself at an inoculum of 10(6); the 333-8-9 line supported a 26% immunity. These data demonstrate a common HSV antigenicity between the murine and hamster transformed lines and further indicate that the HSV genome is involved in transformation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-13502695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-13710227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-163379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-167195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-170223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-190149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-4108570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-4327589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-4348359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-4355112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-4355928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-4363713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/178596-4515492
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
890-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:178596-Animals,
pubmed-meshheading:178596-Antibodies, Viral,
pubmed-meshheading:178596-Antigens, Viral,
pubmed-meshheading:178596-Cell Line,
pubmed-meshheading:178596-Cell Transformation, Neoplastic,
pubmed-meshheading:178596-Cricetinae,
pubmed-meshheading:178596-Cross Reactions,
pubmed-meshheading:178596-Fluorescent Antibody Technique,
pubmed-meshheading:178596-Gammaretrovirus,
pubmed-meshheading:178596-Mice,
pubmed-meshheading:178596-Mice, Inbred BALB C,
pubmed-meshheading:178596-Simplexvirus,
pubmed-meshheading:178596-Ultraviolet Rays
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pubmed:year |
1976
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pubmed:articleTitle |
Cross-reacting herpes simplex virus antigens in hamster and mouse cells transformed by ultraviolet light-inactivated herpes simplex virus type 2.
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pubmed:publicationType |
Journal Article,
In Vitro
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