Linked Life Data

17855658

Source:http://linkedlifedata.com/resource/pubmed/id/17855658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2007-9-14
pubmed:abstractText
In a previously published insertional mutagenesis screen for candidate brain tumor genes in the mouse using a Moloney mouse leukemia virus encoding platelet-derived growth factor (PDGF)-B, the Sox10 gene was tagged in five independent tumors. The proviral integrations suggest an enhancer effect on Sox10. All Moloney murine leukemia virus/PDGFB tumors had a high protein expression of Sox10 independently of malignant grade or tumor type. To investigate the role of Sox10 in gliomagenesis, we used the RCAS/tv-a mouse model in which the expression of retroviral-encoded genes can be directed to glial progenitor cells (Ntv-a mice). Both Ntv-a transgenic mice, wild-type, and Ntv-a p19Arf null mice were injected with RCAS-SOX10 alone or in combination with RCAS-PDGFB. Infection with RCAS-SOX10 alone did not induce any gliomas. Combined infection of RCAS-SOX10 and RCAS-PDGFB in wild-type Ntv-a mice yielded a tumor frequency of 12%, and in Ntv-a Arf-/- mice the tumor frequency was 30%. This indicates that Sox10 alone is not sufficient to induce gliomagenesis but acts synergistically with PDGFB in glioma development. All induced tumors displayed characteristics of PNET-like structures and oligodendroglioma. The tumors had a strong and widely distributed expression of Sox10 and PDGFR-alpha. We investigated the expression of Sox10 in other human tumors and in a number of gliomas. The Sox10 expression was restricted to gliomas and melanomas. All glioma types expressed Sox10, and tumors of low-grade glioma had a much broader distribution of Sox10 compared with high-grade gliomas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1541-7786
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
891-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17855658-Animals, pubmed-meshheading:17855658-Astrocytoma, pubmed-meshheading:17855658-Brain Neoplasms, pubmed-meshheading:17855658-Chickens, pubmed-meshheading:17855658-DNA-Binding Proteins, pubmed-meshheading:17855658-Gene Expression Regulation, Neoplastic, pubmed-meshheading:17855658-Glioblastoma, pubmed-meshheading:17855658-Glioma, pubmed-meshheading:17855658-High Mobility Group Proteins, pubmed-meshheading:17855658-Humans, pubmed-meshheading:17855658-Intermediate Filament Proteins, pubmed-meshheading:17855658-Melanoma, pubmed-meshheading:17855658-Mice, pubmed-meshheading:17855658-Nerve Tissue Proteins, pubmed-meshheading:17855658-Platelet-Derived Growth Factor, pubmed-meshheading:17855658-Promoter Regions, Genetic, pubmed-meshheading:17855658-SOXE Transcription Factors, pubmed-meshheading:17855658-Transcription Factors
pubmed:year
2007
pubmed:articleTitle
Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis.
pubmed:affiliation
Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory C11, Dag Hammarskjoldsv 20, S-751 85 Uppsala, Sweden. Maria.Ferletta@genpat.uu.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't