Source:http://linkedlifedata.com/resource/pubmed/id/17854859
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2007-12-6
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| pubmed:abstractText |
Aquaporin-1 (AQP-1) has been found to be important in bile formation across cell membranes of the biliary epithelium, and thus it has been suggested that AQP-1 is involved in the pathogenesis of hepatobiliary disease. To clarify the role of AQP-1 in the development of intrahepatic cholangiocarcinoma, we determined AQP-1 expression in the normal bile duct, 21 cases of biliary dysplasia, and in 112 cases of intrahepatic cholangiocarcinoma by immunohistochemical analysis. Mucus core protein 5AC expression, a poor prognostic marker of intrahepatic cholangiocarcinoma, was also assessed in intrahepatic cholangiocarcinoma cases. High (>50%) expression of AQP-1 was detected in 16% (9/58) of the normal large bile ducts examined, and in 48% (10/21) of the biliary dysplasia samples originating from large bile ducts. High (>50%), low (<or=50%), and negative AQP-1 expression was observed in 46 (41%), 20 (19%), and 46 (41%) cases of intrahepatic cholangiocarcinoma, respectively. Large tumor size (>40 mm) and poorly differentiated histology were significantly more prevalent in the negative AQP-1 group than in the high AQP-1 group. Low or negative AQP-1 expression was associated with positive lymph node metastasis (P=.0001). AQP-1 expression was found to inversely correlate with that of mucus core protein 5AC, and their distributions tended to be complementary. The low and negative AQP-1 expression was an independent prognostic factor by multivariate survival analysis. We concluded that AQP-1 is up-regulated in biliary dysplasia, as compared with in the normal large bile duct, and down-regulation of AQP-1 is associated with mucin production and aggressive progression of intrahepatic cholangiocarcinoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0046-8177
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
38
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1819-25
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:17854859-Adult,
pubmed-meshheading:17854859-Aged,
pubmed-meshheading:17854859-Aged, 80 and over,
pubmed-meshheading:17854859-Aquaporin 1,
pubmed-meshheading:17854859-Bile Duct Neoplasms,
pubmed-meshheading:17854859-Bile Ducts, Intrahepatic,
pubmed-meshheading:17854859-Cholangiocarcinoma,
pubmed-meshheading:17854859-Disease Progression,
pubmed-meshheading:17854859-Down-Regulation,
pubmed-meshheading:17854859-Female,
pubmed-meshheading:17854859-Gene Expression,
pubmed-meshheading:17854859-Humans,
pubmed-meshheading:17854859-Immunohistochemistry,
pubmed-meshheading:17854859-Kaplan-Meier Estimate,
pubmed-meshheading:17854859-Male,
pubmed-meshheading:17854859-Middle Aged,
pubmed-meshheading:17854859-Mucin 5AC,
pubmed-meshheading:17854859-Mucins,
pubmed-meshheading:17854859-Prognosis
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Down-regulation of aquaporin-1 in intrahepatic cholangiocarcinoma is related to tumor progression and mucin expression.
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| pubmed:affiliation |
Department of Pathology, Hamanomachi Hospital, Fukuoka 810-8539, Japan. aishima-s@hamanomachi.jp
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| pubmed:publicationType |
Journal Article
|