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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-10-9
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pubmed:abstractText |
Exendin-4 (Ex4) is a peptide found in the lizard Heloderma suspectum, and it has a high similarity to glucagon-like peptide 1 (GLP-1). It induces insulin secretion without the risk of hypoglycemic episodes. Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly expressed in neurons. Recent studies have shown that this kinase regulates glucose-stimulated insulin secretion. Cdk5 inhibition enhances insulin secretion under conditions of stimulation by high glucose, but not low glucose. In the present study, we examined whether R-roscovitine (R-ros), a Cdk5 inhibitor, enhances insulin secretion induced by Ex4. R-ros induced Ex4-dependent insulin secretion under conditions of high glucose, but not low glucose in MIN6B1 cells. The enhancement by R-ros was also observed in db/db mice, a mouse model of type 2 diabetes. Moreover, long-term treatment with Ex4 and R-ros significantly improved HbA1c compared with treatment using only Ex4. These results suggest that a co-application of R-ros and Ex4 may become a promising therapy for the treatment of type 2 diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 5,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/exenatide,
http://linkedlifedata.com/resource/pubmed/chemical/roscovitine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1880-6546
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17854513-Age Factors,
pubmed-meshheading:17854513-Animals,
pubmed-meshheading:17854513-Blood Glucose,
pubmed-meshheading:17854513-Cell Line,
pubmed-meshheading:17854513-Cyclin-Dependent Kinase 5,
pubmed-meshheading:17854513-Dose-Response Relationship, Drug,
pubmed-meshheading:17854513-Glucose,
pubmed-meshheading:17854513-Glucose Tolerance Test,
pubmed-meshheading:17854513-Hemoglobin A, Glycosylated,
pubmed-meshheading:17854513-Hypoglycemic Agents,
pubmed-meshheading:17854513-Insulin,
pubmed-meshheading:17854513-Insulin-Secreting Cells,
pubmed-meshheading:17854513-Male,
pubmed-meshheading:17854513-Mice,
pubmed-meshheading:17854513-Mice, Obese,
pubmed-meshheading:17854513-Peptides,
pubmed-meshheading:17854513-Protein Kinase Inhibitors,
pubmed-meshheading:17854513-Purines,
pubmed-meshheading:17854513-Venoms
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pubmed:year |
2007
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pubmed:articleTitle |
A Cdk5 inhibitor enhances the induction of insulin secretion by exendin-4 both in vitro and in vivo.
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pubmed:affiliation |
Department of Physiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558 Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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