Linked Life Data

17853688

Source:http://linkedlifedata.com/resource/pubmed/id/17853688

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-9-14
pubmed:abstractText
The effects of prostaglandin PGE2 on apoptosis and antioxidant enzyme activities were studied in two coelomocyte fractions of holothurian Eupentacta fraudatrix in vitro and in vivo. PGE2 (10(-8) - 10(-6) M) modulated apoptosis in a time- and concentration-dependent manner in both fractions studied in vitro. In vivo, PGE2 induced apoptosis at concentrations of 0.1-1 microg/g in the fraction enriched with morula-like cells. Phagocytes were more sensitive to the regulating effect of PGE2. In this fraction, PGE2 induced apoptosis at concentrations from 0.01 to 1 microg/g, while PGE2 at 10 microg/g demonstrated an antiapoptotic effect. In all experiments, apoptosis development was accompanied by a disbalance of the antioxidant enzyme system, primarily, decreased catalase activity.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1026-3470
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-82
pubmed:meshHeading
pubmed:articleTitle
[Apoptosis-modulating effect of prostaglandin E2 in coelomocytes of holothurian Eupentacta fraudatrix depends on the cell antioxidant enzyme status].
pubmed:publicationType
Journal Article, English Abstract