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rdf:type |
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lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0030705,
umls-concept:C0152035,
umls-concept:C0205314,
umls-concept:C0242647,
umls-concept:C0332307,
umls-concept:C0449258,
umls-concept:C0679622,
umls-concept:C1510411,
umls-concept:C1521828,
umls-concept:C1704259,
umls-concept:C1705535,
umls-concept:C1705987
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pubmed:issue |
11
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pubmed:dateCreated |
2008-3-13
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pubmed:abstractText |
To detect the t(11;18) chromosome translocation in different stages of mucosa-associated lymphoid tissue (MALT) lymphoma, we established a RT-PCR method by adopting three new primer pairs and using the RNA extracted from the paraffin tissues to amplify the t(11;18) fusion gene API2-MALT1 in shorter lengths. Our results showed five key findings, which are (a) higher detection rates of t(11;18) (21.13%) in Chinese patients with transformed MALT lymphoma, (b) lower detection rates of t(11;18) in stomach MALT lymphoma, (c) different organ localizations of MALT lymphoma in Chinese patients, (d) higher nuclear expression rates of Bcl-10 in low grade MALT (51.72%), and (e) lower response rates (50% CR, and 50% PR) to anti-H.-pylori therapy. These findings suggest novel pathways for low-grade MALT lymphoma to be progressed into transformed MALT lymphoma. This study also suggests that amplification of shorter length of PCR products from the paraffin-fixed tissues increases sensitivity, which is significant in improving the selection of the therapeutic regimen and assessing the prognosis of the disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1042-8194
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pubmed:author |
pubmed-author:DrewM AMA,
pubmed-author:GaoZifenZ,
pubmed-author:HuangXuebiaoX,
pubmed-author:JingHongmeiH,
pubmed-author:KeXiaoyanX,
pubmed-author:LeeV SVS,
pubmed-author:WangJijunJ,
pubmed-author:WangJingJ,
pubmed-author:YangXiao-FengXF,
pubmed-author:ZhaoLinzhiL,
pubmed-author:ZhaoWeiW,
pubmed-author:ZhouXiaogeX
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2157-66
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pubmed:meshHeading |
pubmed-meshheading:17852708-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:17852708-Algorithms,
pubmed-meshheading:17852708-Anti-Bacterial Agents,
pubmed-meshheading:17852708-Base Sequence,
pubmed-meshheading:17852708-Case-Control Studies,
pubmed-meshheading:17852708-China,
pubmed-meshheading:17852708-Chromosomes, Human, Pair 11,
pubmed-meshheading:17852708-Chromosomes, Human, Pair 18,
pubmed-meshheading:17852708-DNA Mutational Analysis,
pubmed-meshheading:17852708-Disease Progression,
pubmed-meshheading:17852708-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17852708-Gene Frequency,
pubmed-meshheading:17852708-Helicobacter Infections,
pubmed-meshheading:17852708-Humans,
pubmed-meshheading:17852708-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:17852708-Molecular Sequence Data,
pubmed-meshheading:17852708-Oncogene Proteins, Fusion,
pubmed-meshheading:17852708-Signal Transduction,
pubmed-meshheading:17852708-Translocation, Genetic
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pubmed:year |
2007
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|
pubmed:articleTitle |
Higher rates of t(11;18) in Chinese patients with transformed type of MALT lymphoma suggest novel pathways for progression of the disease.
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pubmed:affiliation |
Department of Hematology and Lymphoma Research Center, Peking University Third Hospital, Peking University Health Science Center, Beijing, People's Republic of China. xiaoyank@yahoo.com
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pubmed:publicationType |
Journal Article
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