Source:http://linkedlifedata.com/resource/pubmed/id/17851763
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-6-4
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| pubmed:abstractText |
To have an overview of the role of BRCA1 and BRCA2 genes among Chinese high-risk breast cancer patients, we analyzed 489 such high-risk breast cancer patients from four breast disease clinical centers in China, by using PCR-DHPLC or SSCP-DNA sequencing analysis. Allelotype analysis was done at five short tandem repeat (STR) markers in or adjacent to BRCA1 on the recurrent mutation carriers. For those analyzed both genes, 8.7% of early-onset breast cancer cases and 12.9% of familial breast cancer cases had a BRCA1 or BRCA2 mutation, as compared with the 26.1% of cases with both early-onset breast cancer and affected relatives. For those reporting malignancy family history other than breast/ovarian cancer, the prevalence of BRCA1/2 mutation is about 20.5%, and it was significantly higher than the patients only with family history of breast/ovarian cancer (P = 0.02). The family history of ovarian cancer (26.7% vs. 11.9%) and stomach cancer (23.8% vs. 11.8%) doubled the incidence of BRCA1/2, but the difference did not reach the statistical significance. Two recurrent mutations in BRCA1, 1100delAT and 5589del8, were identified. The recurrent mutations account for 34.8% BRCA1 mutations in our series. Similar allelotypes were detected in most STR status for those harboring the same mutations. The BRCA1 associated tumors were more likely to exhibit a high tumor grade, negative C-erbB-2/neu status and triple negative (ER, PgR and C-erbB-2/neu negative) status (P < 0.05). We recommended the BRCA1 and BRCA2 genetic analysis could be done for high-risk breast cancer patient in Chinese population, especially for those with both early-onset breast cancer and affected relatives. There may be some degree of shared ancestry for the two recurrent BRCA1 mutations in Chinese.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0167-6806
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| pubmed:author |
pubmed-author:CaoMing-ZhiMZ,
pubmed-author:DiGen-HongGH,
pubmed-author:HePing-QingPQ,
pubmed-author:HuZhenZ,
pubmed-author:HuangWeiW,
pubmed-author:LiWen-FengWF,
pubmed-author:LiuXiao-YiXY,
pubmed-author:LiuYan-BingYB,
pubmed-author:LuJin-SongJS,
pubmed-author:LuoJian-MinJM,
pubmed-author:RaoNan-YanNY,
pubmed-author:ShaoZhi-MingZM,
pubmed-author:ShenKun-WeiKW,
pubmed-author:ShenZhen-ZhouZZ,
pubmed-author:SongChuang-GuiCG,
pubmed-author:SuFeng-XiFX,
pubmed-author:WangLeiL,
pubmed-author:WangYong-ShengYS,
pubmed-author:WuJiongJ,
pubmed-author:YangLinL,
pubmed-author:YuanWen-TaoWT,
pubmed-author:ZhangBinB,
pubmed-author:ZhaoLinL,
pubmed-author:ZhouJieJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
99-109
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| pubmed:meshHeading |
pubmed-meshheading:17851763-Alleles,
pubmed-meshheading:17851763-Breast Neoplasms,
pubmed-meshheading:17851763-China,
pubmed-meshheading:17851763-Female,
pubmed-meshheading:17851763-Genes, BRCA1,
pubmed-meshheading:17851763-Genes, BRCA2,
pubmed-meshheading:17851763-Germ-Line Mutation,
pubmed-meshheading:17851763-Humans,
pubmed-meshheading:17851763-Recurrence
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| pubmed:year |
2008
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| pubmed:articleTitle |
The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified.
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| pubmed:affiliation |
Department of Oncology, Breast Cancer Institute, Cancer Hospital/Cancer Institute, Institutes of Biomedical Science, Shanghai Medical College, Fudan University, 270 Dong'an Road, Shanghai 200032, PR China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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