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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-11-12
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pubmed:abstractText |
Recent studies have shown that distinct classes of antimicrobial agents might exert immunomodulatory effects in experimental settings. Daptomycin is the first member of the class of cyclic lipopeptide antibiotics, which exert their antimicrobial activity via a unique mode of action on the bacterial cytoplasmic membrane. Thus, we tested its ability to influence pro-inflammatory cytokines by use of an established experimental model of human endotoxemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0313
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-62
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pubmed:meshHeading |
pubmed-meshheading:17851272-Adjuvants, Immunologic,
pubmed-meshheading:17851272-Anti-Bacterial Agents,
pubmed-meshheading:17851272-Cytokines,
pubmed-meshheading:17851272-Daptomycin,
pubmed-meshheading:17851272-Endotoxemia,
pubmed-meshheading:17851272-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17851272-Humans,
pubmed-meshheading:17851272-Leukocytes,
pubmed-meshheading:17851272-Male,
pubmed-meshheading:17851272-RNA, Messenger,
pubmed-meshheading:17851272-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2008
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pubmed:articleTitle |
Daptomycin does not exert immunomodulatory effects in an experimental endotoxin model of human whole blood.
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pubmed:affiliation |
Division of Clinical Pharmacokinetics, Department of Clinical Pharmacology, University of Vienna, Vienna, Austria.
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pubmed:publicationType |
Journal Article,
In Vitro
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