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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2007-10-22
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pubmed:abstractText |
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5mug/mL. The presence of the carbohydrate slightly affected the antibacterial activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7789-94
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pubmed:meshHeading |
pubmed-meshheading:17851083-Alkylation,
pubmed-meshheading:17851083-Amino Alcohols,
pubmed-meshheading:17851083-Antitubercular Agents,
pubmed-meshheading:17851083-Cell Proliferation,
pubmed-meshheading:17851083-Cells, Cultured,
pubmed-meshheading:17851083-Glycosylation,
pubmed-meshheading:17851083-Microbial Sensitivity Tests,
pubmed-meshheading:17851083-Molecular Structure,
pubmed-meshheading:17851083-Mycobacterium tuberculosis,
pubmed-meshheading:17851083-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives.
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pubmed:affiliation |
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil.
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pubmed:publicationType |
Journal Article
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