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rdf:type |
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lifeskim:mentions |
umls-concept:C0023688,
umls-concept:C0027410,
umls-concept:C0242402,
umls-concept:C0439064,
umls-concept:C0439097,
umls-concept:C0537638,
umls-concept:C0599740,
umls-concept:C1120262,
umls-concept:C1441547,
umls-concept:C1547348,
umls-concept:C1553035,
umls-concept:C1705241,
umls-concept:C1707689,
umls-concept:C1883695
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pubmed:issue |
22
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pubmed:dateCreated |
2007-10-1
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pubmed:abstractText |
Opioid compounds with mixed micro agonist/delta antagonist properties could be used as analgesics with low propensity to induce tolerance and dependence. Here we report the synthesis of a new designed multiple ligand deriving from the micro selective agonist endomorphin-2 and the delta selective antagonist pharmacophore Dmt-Tic. As predicted, the resulting bivalent ligand showed a micro agonist/delta antagonist profile deriving from the corresponding activities of each pharmacophore.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-10479285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-11504820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-11806723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-12031880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-12486185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-12537996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-1279644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-12852751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-14718580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-15009527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-15115401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-15214786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-15574783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-15780619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-16220969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-16335927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-16392810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-1649297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-16513619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-16759107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-16942040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-17339114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-1849997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-2562839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-2563375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-3018217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-4202581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-6281658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-7134034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-8382810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-8529134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-8893006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-9087409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17851080-9145787
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2',6'-dimethyltyrosyl-1,2,3,4-tetrah...,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydroisoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/endomorphin 2
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6876-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17851080-Dipeptides,
pubmed-meshheading:17851080-Drug Design,
pubmed-meshheading:17851080-Ligands,
pubmed-meshheading:17851080-Molecular Structure,
pubmed-meshheading:17851080-Oligopeptides,
pubmed-meshheading:17851080-Receptors, Opioid, delta,
pubmed-meshheading:17851080-Receptors, Opioid, mu,
pubmed-meshheading:17851080-Structure-Activity Relationship,
pubmed-meshheading:17851080-Tetrahydroisoquinolines
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pubmed:year |
2007
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pubmed:articleTitle |
A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.
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pubmed:affiliation |
Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, I-44100 Ferrara, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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