Source:http://linkedlifedata.com/resource/pubmed/id/17850234
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2007-11-5
|
| pubmed:abstractText |
If an ABO-incompatible heart is transplanted into an infant before natural antibodies have developed to the specific donor carbohydrate A/B antigen(s), then B-cell tolerance to the donor A/B antigen is achieved, and these antibodies never develop. Anti-carbohydrate antibodies play a role in the rejection of wild type (WT) and alpha1,3-galactosyltransferase gene-knockout (GT-KO) pig xenografts. We investigated development of these antibodies in infant baboons and humans. Serum samples from infant baboons (n = 42) and humans (n = 42) were tested by flow cytometry for immunoglobulin M and immunoglobulin G binding to peripheral blood mononuclear cells from WT and GT-KO pigs, and for complement-dependent cytotoxicity. The presence of anti-blood group antibodies was tested in baboon serum. In infant baboons and humans, cytotoxic anti-Galalpha1,3Gal antibodies develop during the first 3 months, and steadily increase with age, whereas cytotoxic anti-nonGal antibodies are either absent or minimal in the majority of cases throughout the first year of life. Anti-blood group antibodies were not detected before 16 weeks of age. Our data suggest GT-KO pig organ/cell transplants could be carried out in early infancy in the absence of preformed cytotoxic anti-nonGalalpha1,3Gal antibodies.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0934-0874
|
| pubmed:author |
pubmed-author:AyaresDavidD,
pubmed-author:BaileyLeonardL,
pubmed-author:BuschJamieJ,
pubmed-author:CooperDavid K CDK,
pubmed-author:EzzelarabMohamedM,
pubmed-author:HaraHidetakaH,
pubmed-author:IjzermansJan N MJN,
pubmed-author:LinYih JYJ,
pubmed-author:LongCassandraC,
pubmed-author:ManjiRizwanR,
pubmed-author:RoodPleunie P MPP,
pubmed-author:TaiHao-ChihHC,
pubmed-author:WolfRoman FRF,
pubmed-author:van der WindtDirk JDJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1050-8
|
| pubmed:meshHeading |
pubmed-meshheading:17850234-ABO Blood-Group System,
pubmed-meshheading:17850234-Animals,
pubmed-meshheading:17850234-Animals, Genetically Modified,
pubmed-meshheading:17850234-Antibody Formation,
pubmed-meshheading:17850234-Child Development,
pubmed-meshheading:17850234-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:17850234-Flow Cytometry,
pubmed-meshheading:17850234-Galactosyltransferases,
pubmed-meshheading:17850234-Humans,
pubmed-meshheading:17850234-Immunoglobulin G,
pubmed-meshheading:17850234-Immunoglobulin M,
pubmed-meshheading:17850234-Infant,
pubmed-meshheading:17850234-Infant, Newborn,
pubmed-meshheading:17850234-Leukocytes, Mononuclear,
pubmed-meshheading:17850234-Models, Animal,
pubmed-meshheading:17850234-Papio,
pubmed-meshheading:17850234-Swine,
pubmed-meshheading:17850234-Transplantation, Heterologous
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants.
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| pubmed:affiliation |
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|