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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0034251,
umls-concept:C0035647,
umls-concept:C0082341,
umls-concept:C0175631,
umls-concept:C0182400,
umls-concept:C0243072,
umls-concept:C0303920,
umls-concept:C0597357,
umls-concept:C1621296,
umls-concept:C1956166,
umls-concept:C2827662
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|
pubmed:issue |
20
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|
pubmed:dateCreated |
2007-9-27
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|
pubmed:abstractText |
Sixteen long-chain arylpiperazines bearing the fluorescent moiety 2-phenylimidazo[1,2-a]pyridine were synthesized as fluorescent dopamine D3 receptors ligands (385 nM < Ki < 0.72 nM). The most potent D3 compounds 15a and 19a (Ki = 1.6 and 0.72 nM, respectively) showed good Stokes shift and high quantum yield in ethanol (Phi = 0.74 and 0.66, respectively). In the first attempt, 15a was unable to visualize D3 receptors expressed in CHO cells by epifluorescence microscopy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Oct
|
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pubmed:issn |
0022-2623
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
4
|
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pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
5043-7
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pubmed:meshHeading |
pubmed-meshheading:17850060-Animals,
pubmed-meshheading:17850060-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:17850060-CHO Cells,
pubmed-meshheading:17850060-Cricetinae,
pubmed-meshheading:17850060-Cricetulus,
pubmed-meshheading:17850060-Fluorescent Dyes,
pubmed-meshheading:17850060-Imidazoles,
pubmed-meshheading:17850060-Ligands,
pubmed-meshheading:17850060-Piperazines,
pubmed-meshheading:17850060-Pyridines,
pubmed-meshheading:17850060-Receptors, Dopamine D3
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
4-[omega-[4-arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization.
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|
pubmed:affiliation |
Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Via Orabona, 4, 70125 Bari, Italy.
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pubmed:publicationType |
Journal Article
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