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pubmed:abstractText |
Dilated cardiomyopathy (DCM) represents a large subset of patients with congestive heart failure (HF), and myocardial fibrosis has been shown to be associated with this process. Lysyl oxidase (LOX), a key enzyme, plays a potential role in the biogenesis of connective tissue matrices by catalyzing crosslinks in collagen and elastin. However, the mechanisms involved in the remodeling process during HF are not clearly understood. The present work was aimed to determine the changes in collagen phenotypes, MMPs, TIMPs, and LOX, in DCM and non-failing human hearts. Moreover, the role of TGFbeta in the induction of type III collagen in cardiac fibroblast is determined.
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pubmed:affiliation |
Department of Molecular Cardiology (NB 50), Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
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