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pubmed-article:17848806pubmed:abstractTextBasic secretagogues of connective tissue mast cells act as receptor mimetic agents that trigger mast cells by activating G proteins. This leads to simultaneous propagation of two signaling pathways: one that culminates in exocytosis, while the other involves protein tyrosine phosphorylation and leads to release of arachidonic acid metabolites. We have previously shown that introduction of a peptide that comprises the C-terminal end of G alpha i3 into permeabilized mast cells inhibits basic secretagogue-induced exocytosis [Aridor et al., Science 1993;262:1569-1572]. We investigated whether cell-permeable peptides, composed of the C-terminus of G alpha i3 fused with importation sequences, affect mast cell function.lld:pubmed
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pubmed-article:17848806pubmed:copyrightInfo2007 S. Karger AG, Basellld:pubmed
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pubmed-article:17848806pubmed:volume145lld:pubmed
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pubmed-article:17848806pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:17848806pubmed:articleTitleInhibition of basic secretagogue-induced signaling in mast cells by cell permeable G alpha i-derived peptides.lld:pubmed
pubmed-article:17848806pubmed:affiliationAllergene Ltd., Ramat Gan, Israel.lld:pubmed
pubmed-article:17848806pubmed:publicationTypeJournal Articlelld:pubmed
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