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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-21
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pubmed:abstractText |
Basic secretagogues of connective tissue mast cells act as receptor mimetic agents that trigger mast cells by activating G proteins. This leads to simultaneous propagation of two signaling pathways: one that culminates in exocytosis, while the other involves protein tyrosine phosphorylation and leads to release of arachidonic acid metabolites. We have previously shown that introduction of a peptide that comprises the C-terminal end of G alpha i3 into permeabilized mast cells inhibits basic secretagogue-induced exocytosis [Aridor et al., Science 1993;262:1569-1572]. We investigated whether cell-permeable peptides, composed of the C-terminus of G alpha i3 fused with importation sequences, affect mast cell function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha Subunit...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Gnai2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Gnai3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin beta3,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2,
http://linkedlifedata.com/resource/pubmed/chemical/Transducin,
http://linkedlifedata.com/resource/pubmed/chemical/p-Methoxy-N-methylphenethylamine
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0097
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pubmed:author |
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pubmed:copyrightInfo |
2007 S. Karger AG, Basel
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pubmed:issnType |
Electronic
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-40
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17848806-Amino Acid Sequence,
pubmed-meshheading:17848806-Animals,
pubmed-meshheading:17848806-Cell Membrane Permeability,
pubmed-meshheading:17848806-Drug Evaluation, Preclinical,
pubmed-meshheading:17848806-GTP-Binding Protein alpha Subunit, Gi2,
pubmed-meshheading:17848806-GTP-Binding Protein alpha Subunits, Gi-Go,
pubmed-meshheading:17848806-Histamine Release,
pubmed-meshheading:17848806-Inflammation Mediators,
pubmed-meshheading:17848806-Integrin beta3,
pubmed-meshheading:17848806-Mast Cells,
pubmed-meshheading:17848806-Molecular Sequence Data,
pubmed-meshheading:17848806-Peptide Fragments,
pubmed-meshheading:17848806-Peptides,
pubmed-meshheading:17848806-Phosphorylation,
pubmed-meshheading:17848806-Prostaglandin D2,
pubmed-meshheading:17848806-Protein Processing, Post-Translational,
pubmed-meshheading:17848806-Rats,
pubmed-meshheading:17848806-Rats, Wistar,
pubmed-meshheading:17848806-Signal Transduction,
pubmed-meshheading:17848806-Transducin,
pubmed-meshheading:17848806-p-Methoxy-N-methylphenethylamine
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pubmed:year |
2008
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pubmed:articleTitle |
Inhibition of basic secretagogue-induced signaling in mast cells by cell permeable G alpha i-derived peptides.
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pubmed:affiliation |
Allergene Ltd., Ramat Gan, Israel.
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pubmed:publicationType |
Journal Article,
Comparative Study
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