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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2007-9-19
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pubmed:abstractText |
The Prostate Cancer Prevention Trial (PCPT) demonstrated a 24.8% reduction in the 7-year prevalence of prostate cancer among patients treated with finasteride (5 mg daily) compared with that among patients treated with placebo; however, a 25.5% increase in the prevalence of high-Gleason grade tumors was observed, the clinical significance of which is unknown. One hypothesized explanation for this increase is that finasteride reduced prostate volume, leading to detection of more high-grade tumors due to increased sampling density. This possibility was investigated in an observational reanalysis of the PCPT data, with adjustment for sampling density.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1460-2105
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1366-74
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pubmed:meshHeading |
pubmed-meshheading:17848668-Aged,
pubmed-meshheading:17848668-Anticarcinogenic Agents,
pubmed-meshheading:17848668-Bias (Epidemiology),
pubmed-meshheading:17848668-Biopsy, Needle,
pubmed-meshheading:17848668-Enzyme Inhibitors,
pubmed-meshheading:17848668-Finasteride,
pubmed-meshheading:17848668-Humans,
pubmed-meshheading:17848668-Incidence,
pubmed-meshheading:17848668-Logistic Models,
pubmed-meshheading:17848668-Male,
pubmed-meshheading:17848668-Middle Aged,
pubmed-meshheading:17848668-Models, Statistical,
pubmed-meshheading:17848668-Odds Ratio,
pubmed-meshheading:17848668-Prostatic Neoplasms,
pubmed-meshheading:17848668-Rectum,
pubmed-meshheading:17848668-Research Design,
pubmed-meshheading:17848668-Severity of Illness Index,
pubmed-meshheading:17848668-Treatment Outcome,
pubmed-meshheading:17848668-Ultrasonography,
pubmed-meshheading:17848668-United States
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pubmed:year |
2007
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pubmed:articleTitle |
Detection bias due to the effect of finasteride on prostate volume: a modeling approach for analysis of the Prostate Cancer Prevention Trial.
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pubmed:affiliation |
Gamida Cell Ltd, Cell Therapy Technologies, Jerusalem, Israel.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Multicenter Study
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