Linked Life Data

17846000

Source:http://linkedlifedata.com/resource/pubmed/id/17846000

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-9-11
pubmed:abstractText
The presence of hypoxic regions within solid tumours is associated with a more malignant tumour phenotype and worse prognosis. To obtain a blood supply and protect against cellular damage and death, oxygen-deprived cells in tumours alter gene expression, resulting in resistance to therapy. Hypoxia is sensed at the cellular level, leading to the activation of molecular pathways to cope with this stress. The key mediator of hypoxia response is HIF1alpha, a member of the hypoxia-inducible factor (HIF) family of proteins. This protein is a transcription factor that stimulates the expression of a multitude of genes important for adaptation to hypoxia, including those encoding angiogenesis. Angiogenesis is stimulated by vascular endothelial growth factor (VEGF), a HIF target gene, to increase blood flow towards oxygen-deprived tissues. This regulation of angiogenesis by hypoxia and HIF is crucial during embryonic development, but also for recovery after ischemic injury. Angiogenesis is one of the physiological responses to hypoxia. Nevertheless, angiogenesis has also deleterious effects by favouring tumour growth.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1769-6917
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
94 Spec No
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S160-5
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
[Hypoxia and angiogenesis].
pubmed:affiliation
Service d'oncologie radiothérapique, Groupe hospitalier Pitié-Salpêtrière, APHP, 47-83, boulevard de l'Hôpital, 75651 Paris Cedex 13. jean-marc.simon@psl.aphp.fr
pubmed:publicationType
Journal Article, English Abstract