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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-3-19
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pubmed:abstractText |
Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1 *0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0198-8859
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-40
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1783570-Adolescent,
pubmed-meshheading:1783570-Alleles,
pubmed-meshheading:1783570-Child,
pubmed-meshheading:1783570-Child, Preschool,
pubmed-meshheading:1783570-DNA,
pubmed-meshheading:1783570-Dermatomyositis,
pubmed-meshheading:1783570-Disease Susceptibility,
pubmed-meshheading:1783570-Electrophoresis, Agar Gel,
pubmed-meshheading:1783570-Female,
pubmed-meshheading:1783570-Genes, MHC Class II,
pubmed-meshheading:1783570-HLA-DQ Antigens,
pubmed-meshheading:1783570-HLA-DQ alpha-Chains,
pubmed-meshheading:1783570-HLA-DR3 Antigen,
pubmed-meshheading:1783570-Humans,
pubmed-meshheading:1783570-Infant,
pubmed-meshheading:1783570-Linkage Disequilibrium,
pubmed-meshheading:1783570-Male,
pubmed-meshheading:1783570-Molecular Biology,
pubmed-meshheading:1783570-Polymerase Chain Reaction,
pubmed-meshheading:1783570-Risk Factors
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pubmed:year |
1991
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pubmed:articleTitle |
Molecular genetic studies of major histocompatibility complex genes in children with juvenile dermatomyositis: increased risk associated with HLA-DQA1 *0501.
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pubmed:affiliation |
Division of Immunology/Rheumatology, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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