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rdf:type |
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lifeskim:mentions |
umls-concept:C0004916,
umls-concept:C0006669,
umls-concept:C0025474,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0039663,
umls-concept:C0042401,
umls-concept:C0221464,
umls-concept:C0391871,
umls-concept:C0445254,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578
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pubmed:issue |
5
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pubmed:dateCreated |
2007-10-29
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pubmed:abstractText |
Calcitonin gene-related peptide (CGRP) is a sensory neurotransmitter in the rat mesenteric arterial bed. Certain cannabinoids can inhibit, via CB(1) receptors, vasorelaxant responses to electrical field stimulation (EFS) of sensory nerves in the rat mesentery, but the mechanism of the inhibitory effect of the cannabinoid delta 9-tetrahydrocannabinol (THC) is unclear. This study assessed directly the effect of THC on EFS-induced release of CGRP from sensory nerves in the rat mesenteric bed and investigated the possible involvement of cannabinoid receptors and transient receptor potential (TRP) ion channels.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-10052983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-10188977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-10440374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-11334873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-12040079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-12860468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-14712238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-1485073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-15131000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-15205450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-15557084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-15821751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-16630609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-17284670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-2901042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-3278943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-9806337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828286-9931142
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AM 251,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Methoxamine,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1,
http://linkedlifedata.com/resource/pubmed/chemical/Ruthenium Red,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrocannabinol,
http://linkedlifedata.com/resource/pubmed/chemical/capsazepine,
http://linkedlifedata.com/resource/pubmed/chemical/iodopravadoline
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
709-16
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17828286-Animals,
pubmed-meshheading:17828286-Calcitonin Gene-Related Peptide,
pubmed-meshheading:17828286-Capsaicin,
pubmed-meshheading:17828286-Dose-Response Relationship, Drug,
pubmed-meshheading:17828286-Electric Stimulation,
pubmed-meshheading:17828286-Indoles,
pubmed-meshheading:17828286-Male,
pubmed-meshheading:17828286-Mesenteric Arteries,
pubmed-meshheading:17828286-Methoxamine,
pubmed-meshheading:17828286-Neurons, Afferent,
pubmed-meshheading:17828286-Piperidines,
pubmed-meshheading:17828286-Pyrazoles,
pubmed-meshheading:17828286-Rats,
pubmed-meshheading:17828286-Rats, Wistar,
pubmed-meshheading:17828286-Receptor, Cannabinoid, CB1,
pubmed-meshheading:17828286-Ruthenium Red,
pubmed-meshheading:17828286-Tetrahydrocannabinol,
pubmed-meshheading:17828286-Time Factors,
pubmed-meshheading:17828286-Vasodilation
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pubmed:year |
2007
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pubmed:articleTitle |
Delta 9-tetrahydrocannabinol inhibits electrically-evoked CGRP release and capsaicin-sensitive sensory neurogenic vasodilatation in the rat mesenteric arterial bed.
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pubmed:affiliation |
Centre for Integrated Systems Biology & Medicine, School of Biomedical Sciences, University of Nottingham, Nottingham, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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