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rdf:type |
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lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0016904,
umls-concept:C0018549,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0022655,
umls-concept:C0026809,
umls-concept:C0030685,
umls-concept:C0220839,
umls-concept:C0391871,
umls-concept:C0392756,
umls-concept:C0439799,
umls-concept:C0680255,
umls-concept:C0754471,
umls-concept:C1283071,
umls-concept:C1416595,
umls-concept:C1963578
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pubmed:issue |
6
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pubmed:dateCreated |
2007-11-12
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pubmed:abstractText |
Deletion of TREK-1, a two-pore domain K(+) channel (K(2P)) activated by volatile anaesthetics, reduces volatile anaesthetic potency in mice, consistent with a role for TREK-1 as an anaesthetic target. We used TREK-1 knockout mice to examine the presynaptic function of TREK-1 in transmitter release and its role in the selective inhibition of glutamate vs GABA release by volatile anaesthetics.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-10321245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-10775263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-10835347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-11605899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-12559116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-12604696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-1353788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-14742687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-15175651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-15491783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-15798028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-16126282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-16174800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-16174801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-16397088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-16409641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-17099720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-17375039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-9579514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17828284-9628867
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Halothane,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Tandem Pore...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Presynaptic,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/potassium channel protein TREK-1
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
939-45
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17828284-Anesthetics, Inhalation,
pubmed-meshheading:17828284-Anesthetics, Local,
pubmed-meshheading:17828284-Animals,
pubmed-meshheading:17828284-Blotting, Western,
pubmed-meshheading:17828284-Brain Chemistry,
pubmed-meshheading:17828284-Cerebral Cortex,
pubmed-meshheading:17828284-Glutamic Acid,
pubmed-meshheading:17828284-Halothane,
pubmed-meshheading:17828284-Immunohistochemistry,
pubmed-meshheading:17828284-Mice,
pubmed-meshheading:17828284-Mice, Inbred C57BL,
pubmed-meshheading:17828284-Mice, Knockout,
pubmed-meshheading:17828284-Nerve Endings,
pubmed-meshheading:17828284-Neurotransmitter Agents,
pubmed-meshheading:17828284-Potassium Channels, Tandem Pore Domain,
pubmed-meshheading:17828284-Pulmonary Alveoli,
pubmed-meshheading:17828284-Receptors, Presynaptic,
pubmed-meshheading:17828284-Synaptosomes,
pubmed-meshheading:17828284-Tetrodotoxin,
pubmed-meshheading:17828284-gamma-Aminobutyric Acid
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pubmed:year |
2007
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pubmed:articleTitle |
Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.
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pubmed:affiliation |
Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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